The more I look through the datamine, the more certain I am that the most 'canon' (if you care about that) Origin pairings for Minthara are Karlach and Gale. Of the companions, they're the ones she has the most detailed conversations with and about. She treats Karlach with great care and a consistent compassion she rarely shows for anyone else, and for all that she pretends to not know Gale's name she's very invested in his pursuing greater power and disappointed if he rejects it. Of all the companions that she mentions in her topical greetings, they're among the only ones that get multiple conversation full conversation trees dedicated to talking to/about them, instead of one or two line quips. They (and Lae'zel) are the companions whose lives it feels like she's invested in, to a greater or lesser extent.
I'm not arguing against shipping her with other people (my longfic is pairing her with Isobel (and eventually Aylin) of all people, and yes setting that up to work believably is one hell of a lift), but every time I delve into the datamine I come face to face with the evidence that the two people in camp that Minthara cares the most about are Karlach and Gale.