August Jacobsen (September 9, 1868 - 1955) was a Norwegian landscape painter. He originally trained as a photographer so that he could take over his father's shop in Stavanger, but he wanted to paint. No school really suited him, whether in Paris or Copenhagen, but he traveled widely, sponging up inspiration, and developing into a capable (post-)Impressionist...

In this article, we will discuss Intravenous Mesna. So, let’s get started. Intravenous Mesna Hemorrhagic cystitis produced by ifosfamide is dose dependent (Table 4). At a dose of 1.2 g/m2 ifosfamide administered daily for 5 days, 16 to 26% of the patients who received conventional uroprophylaxis (high fluid intake, alkalinization of the urine, and the administration of diuretics) developed…

In this article, we will discuss Oral Mesna. So, let’s get started. Oral Mesna Clinical studies comparing recommended intravenous and oral Mesna dosing regimens demonstrated incidences of grade 3 to 4 hematuria of <5%. Study 7 was an open label, randomized, two-way crossover study comparing three intravenous doses with an initial intravenous dose followed by two oral doses of Mesna in patients…

Mesna and Dosing Instructions

In this article, we will discuss Mesna and Dosing Instructions. So, let’s get started. Dosing Instructions Advise the patient to take Mesna at the exact time and in the exact amount as prescribed. Advise the patient to contact their healthcare provider if they vomit within 2 hours of taking oral Mesna, or if they miss a dose of oral Mesna

In this article, we will discuss Mesna (Absorption). So, let’s get started. Absorption Following oral administration, peak plasma concentrations were reached within 1.5 to 4 hours and 3 to 7 hours for free mesna and total mesna (mesna plus dimesna and mixed disulfides), respectively. Oral bioavailabilityaveraged 58% (range 45 to 71%) for free mesna and 89% (range 74 to 104%) for total mesna…

Mesna and Benzyl Alcohol Toxicity

In this article, we will discuss Mesna and Benzyl Alcohol Toxicity. So, let’s get started. Benzyl Alcohol Toxicity • Advise patients that serious adverse reactions are associated with the benzyl alcohol found in Mesna and other medications in premature neonates and low-birth weight infants