I have a million ideas for an Alpha Flight retelling (you know like how there are a million different iterations for Spider-Man, we get a different Alpha Flight story).
One of my ideas is for Lionel Jefferies. After tricking his way out of the mental hospital, Lionel plots his revenge. Instead of creating a race of Omega Creatures (a weird and out of pocket plot), he just wants revenge on his brother, Madison, for keeping him locked away for so long.
However he needs a job, but he can't go back to medicine because he can't get his licence reinstated.
The Canadian Government makes a deal with Lionel. They'll let him practice medicine, but only at their government run orphanage Hull House.
In 616, Hull House is an home for mutant orphans who are later inducted into Alpha Flight (often against their will). In this story it functions as a group home but also part of this new program by the Canadian Government in which parents with mutant children can give their kids over to the state if they don't want them. The government claims they'll help the kids learn to use their powers and make them fit for human society but in reality it's just a super human training camp.
The Canadian government hires Lionel to act as a doctor to the mutant patients. He works their whole doing super human villian stuff at night. He also forms bonds with several of the children.
The kids staying in Hull House in this universe are:
Laura Dean/Pathway
Kara Kilgrave/Purple Girl
Arlette Truffaut/Murmur
Adrian Corbo/Flex
Jared Corbo/Radius
Lilli Stephens/Ghost Girl
Eventually Lionel catches on to Department H's scheme. He decides to take the kids and run. They all live in his hideout, he trains them to use their powers, and is a surprisingly good father figure. They try their best to stay off Alpha Flight's radar and Lionel's quest for revenge is complicated by his new found family and paternal responsibilities.
Maybe the kids form their own anti-Alpha Flight. They call themselves the new Omega Flight or as @severalmoremutants suggested ADK (Alpha Decay)









