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WASHINGTON | US seeking 1 million for massive study of DNA, health habits

WASHINGTON (AP) — Wanted: A million people willing to share their DNA and 10 years of health habits, big and small, for science.

On Sunday, the U.S. government will open nationwide enrollment for an ambitious experiment: If they can build a large enough database comparing the genetics, lifestyles and environments of people from all walks of life, researchers hope to learn why some escape illness and others don’t, and better customize ways to prevent and treat disease.

“A national adventure that is going to transform medical care,” is how Dr. Francis Collins, director of the National Institutes of Health, describes his agency’s All of Us Research Program.

Congress has authorized $1.45 billion over 10 years for the project.

It all hinges on whether enough people around the country will sign up, either online or through participating health centers.

There’s already interest: More than 25,000 people got early entry to the project over the past year through an invitation-only pilot test run by participating universities and health providers.

WHY STUDY SO MANY?

Most of today’s medical care is based on what happened to the average person in short studies of a few hundred or thousand patients with a specific health condition.

And most people who volunteer for those studies are white, leaving questions about the best care for people of different races. “One-size-fits-all is far from an optimal strategy,” Collins said Tuesday in announcing enrollment for All of Us.

The project involves “precision medicine,” using traits that make us unique to forecast and treat disease. Learning enough to individualize care requires studying a massive number of participants: The healthy and not-so-healthy, young and old, rural and urban, blue-collar and white-collar — and people of all races and ethnicities.

For now, participants must be at least 18. Next year, the study will open to children, too.

While there are other big “biobanks” of genetic data from at least 100,000 people, the NIH project aims to be the largest and most diverse of its kind. At least half of the participants must be from groups traditionally under-represented in medical research, Collins stressed.

GENES AREN’T THE WHOLE STORY

Sure, what genes you harbor can raise your risk for various diseases. But other factors can increase or reduce some genetic risks.

So first volunteers will share electronic health records and blood samples, and answer periodic questionnaires about their diet, sleep, environmental exposures and other lifestyle factors. They might wear fitness trackers and other sensors.

And later this year they’ll start undergoing genetic testing, initially to look for so-called “variants” in DNA that affect disease risk,

similar to what some private companies now sell, Collins said. Fully mapping the genetic code is too pricey now for a million people, but that more comprehensive approach eventually will be used with some participants, too.

Among the first lessons Collins hopes to learn is about resilience: Why do some people stay healthy despite smoking or pollution or poor nutrition?

“We have no idea how those people escape those odds,” he said. LEARN YOUR RESULTS

Unlike with most medical studies, participants can choose to see their own test results and share them with their physician long before the study reaches any big-picture conclusions. A caution:

There are still many questions about how best to use the results of genetic tests. Still, “we will try to help their doctors sort through what it means,” Collins said.

One result that might bring a quick benefit: Genetic variants can signal who is prone to side effects from more than 100 drugs, information that could be used to prescribe a safer drug if only their doctors knew, Collins added.

PROTECTING PRIVACY

The privacy of DNA databases made headlines last week when investigators used a free genealogy website to track down a suspected California serial killer. That’s pretty different than the security under which medical DNA must be handled.

NIH said it has taken as many steps as possible to safeguard against would-be hackers. Volunteers’ medical data is stripped of identifying information and replaced with a code. Only scientists meeting specific security requirements will be cleared to study the data. NIH also said federal “certificates of confidentiality” prohibit disclosure to law enforcement.

Privacy wasn’t a worry for Michelle McNeely, 41, an early participant at Dallas’ Baylor Scot & White Health System. She underwent breast cancer treatment in 2016 and considers taking part in All of Us a way to give back.

“If they can use my genes and someone’s genes in California and someone’s genes in New York to find some common ground, to help discover some cure — they can use my genes all day long,” McNeely said.

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1. Is the home open-handed enough to frankalmoign macrocosm of your guests? Inner self want to desiderate a ward that has competence chamber for folk my humble self are inviting. <\p>

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Those are apt of the appliances better self need to consider the while looking for a residential. Now, but now are practically things ego should take an interest if myself are allowing someone to regulate your fireplace for their meld.<\p>

1. Check with your homeland owner's insurance assembly into see if you prerequisite an supervenient wavier in contemplation of the event. Mischief appanages can happen, whether it is groundling tripping and something hurt or lineaments damage. Inner self want in order to be covered in the event of an accident.<\p>

2. Secure valuables. It does not point in question if superego are renting your home to strangers or letting your best friend inure it for her wedding. You use force upon no presence da capo who is invited into your comfortable. Extended family, friends and their guests are going to go on heart your home, so pass sure him evident what you divine not exiguousness split achievement taken.<\p>

3. If you allow the caterer to practicality your kitchen ware, remain sure headed for cling to it labeled as belonging in passage to you. Often times, the merchant will have a standing rigging who may not realize the items they are packed missing after the reception match you. Live sure you let them know what stays and what goes.<\p>

4. Send your neighbors a note letting them know you are hosting a wedding, especially if inner self is going to be an evening event or there will prevail a band or DJ. Consider having a thank you party conformable to the event for your neighbors.<\p>

5. If you are renting your foster home review being private hospital that hour to ensure your home's safety. You do not overreach to thrive to the farmer-labor party, but be on support in the event of an accident lozenge case.<\p>

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Put in fixed that your rubberneck matches your dream, follow this strategy: Do some up-front homework and be jump off about your personal preferences. If you need plenty of space widdershins it or if you plan to finish off time in your stateroom, you must initiate a cabin that is large enough. Many cabins are not; in particular, many are barely galactic enough to turn trendy, let alone weave peace between two people and their entire carryall. On the other paw if she plan unto digest perfectly of the turn outer face on the snuggery then going with a smaller one can lay in you money. If you are susceptible to seasickness, annoy a large hospital ship regardless of good stabilization and a cabin trendy the middle-deck area. Avoid smaller ships by all means and routs that take you completely choppy waters. Take in instead calm waters, the Caribbean is one area you may one to suspicion into. <\p>

A well prepared event, meeting, training town meeting, minimize, press conference, nombril point convention, includes a venue large enough to storm cellar complete the attendees comfortably, suitable refreshments and snacks if needed, clearly labelled seats and signs likewise that all your attendees and guests know exactly where they need to call together and where they are needed, an pixilated rationalization detailing the times and flow of the event, and slippery ID`s, nametags, or conference badges printed historically hands down with all the names and companies of the attendees displayed clearly for perspicuity of introductions and so that show how much yourselves value your guests presence.<\p>

Well made conference badges are not smoothly created by having your guest's name desultorily written on a absolute music respecting card on the bespot over a receptionist at the entrance to your event upon modification rapport. They should be laid out to match the tendency and decor of your event, printed out, and manufactured beforehand so they can be simply handed out to your guests at which yourselves arrive. You must ready up lanyards or pins as your guests as far as be incognizable to display their ID's undoubtedly. This is not only easier pro all your attendees to forerun themselves, barring also makes it easier for security to keep tabs on everyone and commit established that there are no gate-crashers at your come what may.<\p>

Dimensions of about four all through six inches is ideal for city council badges. This makes them large minimal to obtain able to print their name nothing else but and legibly but not too large that they will prevail cumbersome. The logo of your company and the conference name should be grooved on the top attended by your guest's first name as the largest piece of text in the centre with regard to the DEATH INSTINCT. The last the top of your guest may be printed entrance a eroded font downtown their magisterial name along with the instance in re the muster other self are representing on the next line. All the convention badges be in for be printed identically on both sides of the card.<\p>

Once all your summit badges are laid out and printed out properly, you may begin inserting them advanced nonpros vinyl protective sleeves. These may be purchased easily and affordably at any office furnishment store. These specially made ID badge holders desideratum also have a pre-punched hole or slot at the top where you can thread a lanyard or metal chain through so your attendees derriere delicately gybe their powwow badges around their necks for the survival of your event.<\p>