#labcompliance

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Each year, the AMA issues updates to the CPT code set, and 2025 brings meaningful shifts for laboratory CPT codes. With 270 new codes, revisions, and deletions across specialties, labs must adapt or risk denials. Among the notable additions: G0567 (Hepatitis C screening via amplified probe technique) now aligns with the Clinical Laboratory Fee Schedule (CLFS). Other new codes include 81195 for cytogenomic mapping in hematologic malignancies and 81558 for allograft rejection mRNA profiling. Labs should update their master billing catalogs, staff training, and audit workflows to reflect these changes. Partnering with expert services like AnnexMed’s laboratory coding support helps ensure accurate transitions.