TOP 10: Binding of Isaac Item Combinations
Okay first off, this is probably one of the WORST combinations you can ever receive in a game. If you don't already know, IPECAC+My Reflection makes explosive shots not only curver towards you, but never fall to the ground, unless coming in contact with a wall, thus making it near impossible to kill enemies. Why is it number 10? Because I like a good laugh every now and then.
9. Guppy's Tail+Skeleton Key+The Left Hand
In number 9 we have the combination that will begin a red chest apocalypse. Guppy's Tail increasing the chance for golden chests, Skeleton Key giving you and infinite amount of keys, and The Left Hand turning all chests, with red chests. Yes, so that means a shit-ton of flies, spirit hearts, pills, and even some pedestal items.
8. Whore of Babylon+Guppy's Paw
To put it simply, if you use it everytime, you can stay permanently in the cursed state.
7. Guppy+Pentagram/Book of Revelations/Book of Belial
This combination is one that I use a lot when I'm playing. More devil rooms, more lives, overall you will respawn with those dark items.I find this one very useful, since most items from the devil room are mass damage ups, and you will always keep them as long as you have lives.
6. Technology 2+Polyphemus+Mulligan
I guess a fairly average combination would be this. The laser from Techology 2 will get a mass damage up, yet still fire constantly. Mulligan added to that, Blue Flies will spawn at an extremely high rate.
5. Sacred Heart+Mutant Spider
I've tried this only once, starting it out in Womb 1. Excellent performance. Mutant Spider creating 4 shots at 1/4 the normal rate of shots, and Sacred Heart increasing the size and adding mass damage. Think about it. 4 huge shots with massive damage up? Yes, I like it.
4. Technology+Polyphemus+Wiggle Worm
The perfect combination if you seem to be getting a shit-load of monsters in one room or you're going through bullet-hell (all the time in Cathedral). This combination not only makes your laser curve, but the size upgrade from Polyphemus gives it an effect that really takes up half of the screen. Legit.
I had trouble trying to get a hold of this one. I saw a friend use this, and holy hell, it worked like a charm. It results in the usual Polyphemus being shot in the opposite direction as that of the first arrow key pressed to shoot the missile. Will still shoot missiles as usual and the polyphemus tears will keep shooting when holding the arrow key down.
2. Habit+Book of Revelations+The Battery
Need some spirit hearts? Bro, these things can save your ass in tough situations. Book of Revelations giving you two spirit hearts everytime it is fully charged, The Battery speeding up that charging process, and the Habit giving you more spirit hearts for damage taken. How would you not want a life-saver in the game near the end. Best effects in Sheol and Cathedral for me!
1. Fetus in a Jar+Bobby Bomb+Mr. Mega
This one steals the number 1 spot just barely better than number 2. Like explosions? You'll love this. As some would know, Fetus in a Jar makes you shoot, yes that's right, bombs. Add Bobby Bomb and they home in on enemies. But wait, theres more! Add Mr. Mega, and you get huge ass explosions causing mass damage to enemies.
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