Human IL-8(Interleukin 8) ELISA Kit Basic Information

Feiyue’s Human IL-8 is an ELISA reagent for detection of IL-8 in human serum, plasma or cell with sensitivity, specificity and consistency.

Human IL-8(Interleukin 8) Introduciton

Interleukin 8 (IL-8 or chemokine (CXC motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms. In culture, a 72 amino acid peptide is the major form secreted by macrophages.

Human IL-8(Interleukin 8) ELISA Kit Test method

This kit uses sandwich ELISA to detect the concentration of Human IL-8.

Feiyue’s Human IL-22 is an ELISA reagent for detection of IL-22 in human serum, plasma or cell with sensitivity, specificity and consistency.

IL-22 is produced by several populations of immune cells at a site of inflammation. Producers are αβ T cells classes Th1, Th22 and Th17 along with γδ T cells, NKT, ILC3, neutrophils and macrophages. IL-22 takes effect on non- hematopoietic cells – mainly stromal and epithelial cells. Effects involve stimulation of cell survival, proliferation and synthesis of antimicrobials including S100, Reg3β, Reg3γ and defensins. IL-22 thus participates in both wound healing and in protection against microbes. IL- 22 dysregulation takes part in pathogenesis of several autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and psoriasis.

This kit uses sandwich ELISA to detect the concentration of Human IL-22.