#hif-1

Researchers achieve spontaneous tissue regeneration in mice. Thoughts health innovators?

Researchers at the Lankenau Institute for Medical Research (LIMR), University of California and Allergan have used a primordial form of energy produced in mammals to achieve spontaneous tissue regeneration in mice, without the need for added stem cells.   The new study show that the HIF-1a pathway, an oxygen regulatory pathway predominantly used early in evolution and still used during embryonic…

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.

Semenza GL1.

Author information

1Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

Hypoxia occurs frequently in human cancers and induces adaptive changes in cell metabolism that include a switch from oxidative phosphorylation to glycolysis, increased glycogen synthesis, and a switch from glucose to glutamine as the major substrate for fatty acid synthesis. This broad metabolic reprogramming is coordinated at the transcriptional level by HIF-1, which functions as a master regulator to balance oxygen supply and demand. HIF-1 is also activated in cancer cells by tumor suppressor (e.g., VHL) loss of function and oncogene gain of function (leading to PI3K/AKT/mTOR activity) and mediates metabolic alterations that drive cancer progression and resistance to therapy. Inhibitors of HIF-1 or metabolic enzymes may impair the metabolic flexibility of cancer cells and make them more sensitive to anticancer drugs.

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[ppt] Metabolomics by Magnetic Resonance: From Molecules to Man

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Conditioning Stem Cells to Survive in the Heart

After a heart attack, the heart is a very inhospitable place for implanted stem cells. These cells have to deal with low oxygen levels, marauding white blood cells, toxins released from dead or nearly dead cells, and other nasty things.

Getting cells to survive in this place is essential if the cells are going to provide any healing to he heart. Fortunately, a Chinese group has discovered that…