#hypoxia

Inspired by @m4rkus-gr33n

Humans are not yet done cooking. We're continuing to evolve and adjust to the world around us, the records of our adaptations written in our bodies. We know that there are some environments that can make us unwell. Mountain climbers often succumb to altitude sickness – the body's reaction to a significant drop in atmospheric pressure, which means less oxygen is taken in with each breath. And yet, in high altitudes on the Tibetan Plateau, where oxygen levels in the air people breathe are notably lower than lower altitudes, human communities thrive.

Fandom: How to Train Your Dragon Whumpee: Hiccup Word Count: 1,570 Rating: G Summary: Hiccup discovers the hard way that there are some heights men aren't meant to reach - even on the backs of dragons. Set during HTTYD 1.

@explosiontheory @ihaveglitterbombs @princessalmost @evilwriter37 @autumndragon @whoviankendokaqueenbeewithbooks @mx-iced-latte-faye @twig-the-escaped-cephalopod @ashleybenlove @thedragon-and-hisboy

I dedicate this to all my Maasvers FMCs

Click & Detect

Click3D: a method using click chemistry (a class of reactions that make molecules observable) that achieves high-resolution 3D fluorescence imaging of whole organs at unprecedented depth – for example, imaging hypoxia (inadequate tissue oxygen) in a tumour (as shown here) or in the mouse whole brain

Read the published research article here

Video from work by Iori Tamura and colleagues

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Video originally published with a Creative Commons Attribution 4.0 International (CC BY-NC 4.0)

Published in Science Advances, July 2024

This is easily one of the most bizarre things in my life with this lemon of a body. I've been experiencing this predictable heart rate jump when I stand up, without fail, for over three decades... until the heart rate increase started failing mid-leap.

I thought I just wasn't recovering from a cold in March, went to the doc in late April; my lungs were clear, no high WBC, wasn't a secondary infection. But the symptoms were apparently consistent with heart or lung damage. Doc sent me to the ER. The ER chest CT was clear, but while I was hooked to the ER machines I noticed my oxygen saturation kept doing this slow dropping down to alarmingly low levels--and I felt fine--then slow climbing back to 99%. A few minutes later I was hit by intense fatigue & pain.

I checked it on the fingertip pulse/ox after I got home, still happening, but fingertip machine had difficulty with motion and rapidly changing numbers. I got a wearable bluetooth pulse/ox. I'm still seeing the oxygen saturation dips and it's pretty terrifying, yes, WTF is this meat machine doing now? (My doc thinks leakage between oxygenated and deoxygenated blood, which is not reassuring at all. I have a cardiac referral.)

But seeing my POTS get tripped partway through a jump is *freaky*.

Look at that (about 11am). That's not right. My heart rate started to do the typical POTS jump and crashed to below 50 instead, coinciding with a dramatic O2 drop. What the hell. (full screenshot under readmore)

How long has it been doing this? Is my physical hardware just unable to react to the dysautonomia "speed up" signals? Is this why the fatigue has been increasing way past reasonable?

I had a heart ultrasound and multiple EKGs during the POTS diagnosis, but apparently what I need is a heart ultrasound with "bubble test," which I have never had. I even wore a pulse/ox for a sleep study but this doesn't happen at night! Mostly. It does coincide with activity... frequently... sometimes I am not doing anything... but almost always I am awake.

My POTS is broken and I am so weirded out.