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TADC EDIT!!!TOOK ME 2 DAYS (best to wear ear buds or headphones) (btw don’t mind the miss spelling I was in a rush) (
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TADC EDIT!!!TOOK ME 2 DAYS (best to wear ear buds or headphones) (btw don’t mind the miss spelling I was in a rush) (
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HD18 via Johnny Wilson (2015)
Johnny Wilson dropped yet another video edit "HD18." Watch it now on our site.
https://vimeo.com/150682774
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Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial.
The intensity of chemotherapy for patients with advanced stage Hodgkin's lymphoma was until now not clearly defined. In HD15 study, 2182 patients were randomly assigned to receive 1) eight cycles of escalated BEACOPP (8×B(esc) group), six cycles of escalated BEACOPP (6×B(esc) group), or eight cycles of BEACOPP-14 (8×B(14) group). All patients with a persistent mass after chemotherapy measuring 2.5 cm or larger and positive on PET scan received additional radiotherapy with 30 Gy. In all 3 groups, freedom from treatment failure was not significantly different. However overall survival was significantly better with 6×B (esc) than with 8×B(esc), mainly due to the reduced mortality of chemotherapy. Thus, six cycles of BEACOPP(escalated) should be the treatment of choice for advanced stage Hodgkin's lymphoma. PET done after chemotherapy can guide the need for additional radiotherapy in this setting. In the next generation of study (HD18), the feasibility and outcomes of a further CHX de-escalation to 4 x B(esc) will be tested in patients with complete remission in PET after the initial 2xB(esc). http://www.ncbi.nlm.nih.gov/pubmed/22480758 by MLi