#exicure

Three years ago, I asked in a blog post here What do scientific prizes celebrates? It was a reaction to false claims in press releases by the King Faisal Price and Northwestern University announcing the award of the 2023 King Faisal Prize in Medicine and Science to Chad Mirkin. One of the false claims was that spherical nucleic acids were the basis for more than 1,800 commercial products.Well,…

Discover the unique investment potential of Exicure Inc. Learn about its financial performance, stock price volatility, and future prospects #Exicure #XCUR #InvestmentInsights #StockInsigts #BiotechnologySector #Biotechnology #StockPriceForecasting

Exicure Inc is an early-stage biotechnology company headquartered in Chicago, IL. They focus on developing nucleic acid therapies targeting ribonucleic acid (RNA) against validated targets for neurological disorders and hair loss. Their operations include in-house discovery and development efforts with a dedicated 30 000 sq. ft. facility for nucleic acid synthesis and screening. 6…

82% self-citation and grave misrepresentation in an ACS Nano Focus article

This post is cross-posted at PubPeer. Mirkin and Petrosko review with enthusiasm and even a certain amount of lyricism the properties and applications of Spherical Nucleic Acids, an expression coined by Mirkin to describe particles prepared in the Mirkin group. Out of the 186 cited references, 160 or 82% have Mirkin as an author. Of the 36 other references, 16 are reviews, books or pre-1920…

What do scientific prizes celebrate?

Another scientific prize has been awarded to Chad Mirkin for his work on oligonucleotide-modified gold nanoparticles (or Spherical Nucleic Acids, aka SNAs, as Mirkin calls them since 2012)… whilst SNA company Exicure continues on its “death spiral“. The prize is the 2023 King Faisal Prize (KFP) in Medicine and Science. The KFP and Northwestern press releases show a certain disconnect from…

Spherical Nucleic Acids company Exicure “in survival mode”

In 2011, Mirkin co-founded (with Shad Thaxton) the biotechnology company Exicure to develop the biomedical applications of spherical nucleic acids (SNAs). After an internal research fraud (misreporting of preclinical data) and at least two clinical trials failing to deliver encouraging results, the company seems unlikely to survive 2023. In 2018, Chad Mirkin called me a scientific terrorist for…

Exicure, Inc. (NASDAQ:XCUR) Short Interest Update

Exicure, Inc. (NASDAQ:XCUR) saw a large decline in short interest in November. As of November 30th, there was short interest totalling 1,350,000 shares, a decline of 22.4% from the November 15th total of 1,740,000 shares. Based on an average trading volume of 430,500 shares, the days-to-cover ratio is presently 3.1 days. Approximately 2.4% of the company’s shares are sold short. Shares of NASDAQ…

Allegations of research improprieties at Spherical Nucleic Acids company Exicure

Last Tuesday, Twitter user @NanoSkeptic drew my attention to a report by the company Exicure that develops biomedical applications of Spherical Nucleic Acids. Exicure was founded in 2011 by David Giljohann, Chad Mirkin and Shad Thaxton. Don’t look now, but $XCUR just filed a 12b-25. “alleged research improprieties”https://t.co/bCeiHXXRkq— Nano_Skeptic (@NanoSkeptic) November 16, 2021…