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Schmerzmediator
1 Definition
Als Schmerzmediatoren bezeichnet man schmerzinduzierende Gewebsmetabolite und Mediatoren, die im Rahmen einer Entzündung vermehrt sezerniert werden.
2 Wirkung
Schmerzmediatoren setzen durch rezeptorvermittelte Vordepolarisation der Nozizeptormembran die Reizschwelle der Schmerzrezeptoren und damit die Schmerzempfindlichkeit herab (Nozizeptor-Sensibilisierung). Die Folge ist eine…
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