#enterotoxins

The Scientific Research Notes Of S. Sunkavally (years: 2002-2011).

Enhanced secretion of fluid in starvation has been proposed to worsen any fluid secretion that is already occurring after exposure of the intestine to enterotoxins. The evidence for this is that historical accounts of imposed fasting in civil or military circumstances are associated with fatalities that arise from secretory diarrhoeal disease. In addition, there is also experimental work apparently showing that secretion is enhanced during short term starvation. In experimental animals exposed to fasting and bacterial enterotoxin, the short-circuit current increase on toxin exposure, assumed to represent fluid secretion, is always greater in the animal intestine exposed to E. coli heat stable STa enterotoxin.

Attention is drawn to the fact that human volunteers in a laboratory setting do not develop diarrhoea on fasting. They do develop a reduction in circulating blood volume consistent with lower than usual blood pressure and hypovolaemia. More detailed examination of the well documented historical accounts of sieges and civil forms of enforced starvation confirms the cardiovascular changes but evidence of secretion i.e. diarrhoea, only occurs when contaminated water is exploited or is the sole source of fluid and personal hygiene is problematical. In human situations in which salt is provided, the incidence of diarrhoeal disease is intermittent but with salt deprivation, the incidence increases. Polydipsia is a consistent feature of persistent starvation and it can be assumed that this is a response to the hypovolaemia.

The evidence from short-circuit current studies in fasted experimental animals is reviewed. A close examination of these studies indicates that increases in short-circuit current are unlikely to rep-resent chloride ion section. An alternative explanation is given of enhanced but electrogenic sodium ion uptake in response to the shrinkage in blood volume which cannot be restored by drinking water alone. Evidence from isotope studies has shown that fasting in animals increases sodium ion uptake as well as short-circuit current, making it likely that fasting causes electrogenic sodium ion absorption. Earlier data on the effect of diuretics makes it likely that what has been studied is the involvement of compensatory electrogenic sodium ion absorption and its interruption by certain diuretics. The recent siting of the NKCC2 transporter in the intestinal brush border makes this a viable alternative explanation for the changes in ion currents seen in starvation. There are therefore no compelling reasons for assuming that fasting enhances secretion in man or in animals or that bacterial enterotoxins cause secretion that is exacerbated by starvation. Author(s) Details

Dr. Michael L. Lucas University of Glasgow, Glasgow, G12 8QQ, Scotland, UK.