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Drug discovery: A question of library design
Which approach is best for creating compound libraries for drug discovery?
This Nature review discusses fragment-based drug design and diversity-oriented synthesis.
I believe both approaches have their challenges however diversity-oriented synthesis has the scope to cover more areas of biological space.
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Welcome to The Lab Notebook!
Hello!
I'm an aspiring Organic Chemist living in England. I've created the lab notebook as a means of keeping my papers and notes in one handy place.
As this is my first ever post on Tumblr, I thought I would start as I mean to go on by linking to an insightful review in Angewandte Chemie:
A Planning Strategy for Diversity-Oriented Synthesis
This discusses Diversity-Oriented Synthesis, which is a strategy for creating diverse and complex products from simple starting materials.
(image from Nature, 2011, 470, 42–43 DOI: 10.1038/470042a)
An alternative pdf version can be found here.
20/9/14
