Dissolution Tester – Working Principle, Applications, and Types
A Dissolution Tester LE-DS101, also referred to as a pharmaceutical dissolution tester or tablet dissolution tester, plays an essential role in pharmaceutical laboratories for evaluating how a drug releases from its dosage form into a liquid medium. The dissolution test helps determine the rate and extent of drug release, which is critical for ensuring consistent product performance and regulatory compliance.
What is a Dissolution Tester?
A dissolution tester, also known as a dissolution apparatus or USP dissolution apparatus, is a laboratory instrument used to simulate conditions inside the human body. It measures how quickly active pharmaceutical ingredients (API) dissolve in a specific medium under controlled conditions such as temperature, agitation speed, and time.
Popular systems such as Electrolab dissolution apparatus, Agilent dissolution tester, and tablet dissolution test apparatus are widely used in pharmaceutical research and quality control labs.
Working Principle
The instrument operates by placing tablets or capsules in vessels containing dissolution medium. The system maintains a constant temperature (usually 37°C) and uses paddle dissolution apparatus or basket dissolution apparatus to agitate the medium. Samples are withdrawn at specific intervals to analyze the drug release profile.
Diagram of a Dissolution Tester (Concept Overview)
Vessel (medium container)
Paddle/Basket assembly
Temperature controller
Motor (stirring mechanism)
Sampling ports
Types of Dissolution Testers
Manual Dissolution Tester – Requires manual sampling and monitoring
Automated Dissolution Tester – Handles sampling, analysis, and data recording automatically
USP Apparatus Types – Includes USP Apparatus 1 (basket), USP Apparatus 2 (paddle), and other standardized configurations
The automated dissolution tester is commonly preferred for high-throughput environments due to improved efficiency and reduced human intervention.
Applications of Dissolution Tester
The application of dissolution tester in pharmaceuticals extends across multiple areas:
Drug formulation development
Quality control testing
Batch consistency evaluation
Bioavailability studies
Regulatory compliance testing
These tests ensure that the drug performs consistently and releases the active ingredient within the required time frame.
Key Features to Consider
Temperature control system
Variable stirring speed
Multiple test stations
Sampling accuracy
Compliance with USP dissolution standards
Product Highlight
The Dissolution Tester LE-DS101 (model number: LE-DS101) supports tablet dissolution testing with controlled temperature and variable speed settings. It accommodates multiple vessel configurations, making it suitable for routine pharmaceutical testing.
Conclusion
A laboratory dissolution tester is a critical tool in pharmaceutical analysis, ensuring drug quality, safety, and performance. From manual systems to automated models, instruments like the Dissolution Tester LE-DS101 support accurate and repeatable testing aligned with industry standards.
Learn more about Dissolution Tester LE-DS101
