(heavy dispatch spoilers)
I know that Blazer probably does take the amulet off a reasonable amount but I think my first playthrough (where I was aiming for Friendship Only so went to the movies cos that could be more of a friend-date and so didn't learn about Mandy until later) influenced how I see her and... I guess I'm thinking about her relationship with her powers and The Substance theme starts playing in my head which is always a good sign. Especially given how significant the impact is on Chase... there's implications which are Fun to me. I personally love when Superhero Stories aren't really about the fights and the powers but are about the person behind the mask and how the Great Responsibility of it all which.... oh man I hope S2 has time for Mandy & Robert scenes about this cos there's a lot of potential!! (But even if not the gift of potential is indeed. In our laps. Seizing it and running).
So as a headcanon: I think whenever she first started out as Blazer she either set some boundaries for herself or naturally treated it as a Job that she clocked out of. Whether she was with SDN or not, she had Blazer Hours where she was working, and then was living her life the way anyone with a job would outside of that. Socialising, eating, sleeping, chores, etc. But then the exceptions start creeping in - a particularly hectic day where she feels morally she has to work overtime; skipping a meal or getting less sleep and realising the powers compensate and she doesn't even notice (it doesn't even affect "Mandy" if she tends to those needs at normal times when she's out of the suit); drifting away from lifelong friends the more she has to keep her secret. And those exceptions start happening more and more often until they start looking more like rules. "Mandy" becomes more of a persona than Blazer. She yearns for the normalcy, but has such a strong moral core and drive that she struggles to allow herself it anymore.
I think... it frankly gets to a point where sleeping and eating and resting at all become almost alien to her. She does overtime at SDN, then spends the nights in the field. She's going back to her apartment so infrequently that it stops making sense to have one. Personal effects get pared down to whatever she can keep in her office, the boot of her car (I PRESUME the black car is hers and she was lying about not having one) or a storage unit.
And she doesn't want it! But what does her personal desire matter in the face of a city that needs Blazer more than it needs Mandy. That's probably why she even dates Phenomaman at all honestly - normalcy is literally alien to him, he's probably one of the few people who can keep up with her, but... he's only abnormal on this planet. Maybe he yearns for a return to a normal he can't go back to as well!! (And then when it becomes clear that no... no he doesn't... oo boy that relationship crumbles.)
So when Chase has the amulet and is now wearing it full time to keep him upright, now she's got what she wanted right? WRONG. At least, the way I think she'd feel based on how she expresses her desire for normalcy (and how she relates that to Robert's situation and gravitates towards him for it) is she just... wants to go back to how it was when she started. She wants that balance that she couldn't enforce on herself. But now she's just been torn from Blazer entirely - and, like, she's not going to selfishly demand Chase take a bit of coma-time so she can be Blazer again obviously. But it's cold turkey on a persona that had become her life and there's no way that isn't cataclysmic. She needs a place to live, she needs to eat and sleep again. Fuck!!
Basically... I think despite holding it together at the end of episode 8 and being like "hey, I can get normal drunk now!" (this is a warning sign to ME for copium overdose) the second she exits immediate crisis mode she's going to crash so hard. Robert Robertson III sling your hook mate your male living space, lack of bed and terrible diet has NOTHING on what post S1 Mandy is about to bring to the table. She's "sleeping" in her car/office (if she remembers HOW to sleep), she's forgetting she even has to eat, she's got undiagnosed comorbidities you couldn't even dreaaam of. She gets so restless in the evening she starts going on unhealthily long jogs just to be outside and moving. Someone somewhere has a discussion about the ethics of slipping her black-market Adderall to see if it helps or just makes her worse (probably Prism and Sonar). The Z-team has a pool on when she'll hit Breakdown point and whether it'll be at work that none of them actually intend to cash in on cos it feels way too meanspirited. Etc etc.