If I remember correctly, your guild is 25 man, so make sure that your melee is spread out between whatever boss they are on’s two legs while Dissector is alive so that any given number of mutations that land on them do not 1-shot people (since each mutation causes AoE damage around its target). If your raid composition can afford it, you can time damage reduction cooldowns (Smoke Bomb, Power Word: Barrier, etc.) in melee when the mutations should go out.

Various CC’s should be used on whatever Parasites possible to manage them until they have been eaten by those in the raid who become mutated (Hibernate, Polymorph, etc. Do NOT Cyclone the Parasites, as it makes them immune to the mutation ability to consume them AND takes its cooldown away from the caster!) If too many parasites are in melee where cleaves are preventing them from being CC’d, chain AoE stuns from Warlocks and Shamans in melee to manage them. 

Hunters, mages, monks, priests, and rogues should, for the most part, be left to their own devices when it comes to soaking aims. Hunters can feign death, mages can invis, priests can guise, and rogues can vanish to drop the effect on them completely, while monks can solo soak it once using Zen Meditation (just make sure no one else gets in the way!). If these abilities are on cooldown, or if the target of aim is currently mutated, quick communication is essential to make sure that aim is still soaked effectively. Ensure that only classes with sufficient damage reduction abilities are soaking aims for classes that can not handle it on their own. Hunters with Deterrence and Rogues with Feint are great for this. Classes that cannot handle Aim on their own must remain close enough to the group so that soakers can make it to them in time; classes that can solo it need not worry as much about their positioning. 

Watch timers for Hurl Amber and make sure that no ranged classes are near melee, as poorly placed Amber puddles can cause melee deaths very easily; more so as the fight drags on. Before an amber puddle lands, a small graphic is displayed on the ground, showing where it will land. Players should keep an eye out for this and move away from it before the amber lands to avoid the damage completely (and even minimum graphic settings can see it). After Hurl Amber has landed, the graphic is buggy and occasionally fades in and out of existence, even if the damage zone remains. Try not to fall for this and take unnecessary damage; each Amber puddle will fade shortly before the Hurl Amber is cast again. 

For Firey Edge, my guild typically does not use any raid cooldowns for the first and saves stronger raid cooldowns for the later ones, as they get more powerful over time. If possible, have everyone in the raid set their boss mods to call out in /say when they have been selected as a target of Firey Edge, so that spreading out and away from these targets is easier.

My guild uses Lust and second potions on Poisoned Mind to limit the amount of Catalyst effects we have to deal with. If DPS is high enough, you may not even get a single one this way.

For Manipulator, it may be best to have world markers stationed in each corner of the room for communication purposes so that ranged DPS know what areas to avoid and can communicate where the Kunchong casting Mesmerize is so that they can kill it (ie; “Blue side is pretty clear,” or “Mesmerize, near Green!”). Melee DPS should not attack the Kunchongs, lest they get eaten. Mesmerize can also be cancelled by invisibility effects such as a Priest’s Spectral Guise and a Mage’s Invisibility (IDK if Feign Death breaks it). Breaking Mesmerize this way will reset it completely, making it so the next Kunchong that casts it is random, rather than the same one as would be the case if Mesmerize was broken by damage. Priests can use their Leap of Faith to pull players away from Kunchongs during Mesmerize, but should not be specced into Body and Soul for this, as the movement speed granted will make the target walk faster towards the Kunchong afterwards. Should a Kunchong mature, it should be picked up by a tank as quickly as possible and focused down; its frontal swipe ability can kill melee very easily. 

If your raid has druids, Stampeding Roar should be glyphed for the extra range and used to help the raid deal with Wind Reaver’s Reave ability.

If DPS is low and you’ve made it this far, do not fret, as Locust can be handled for some time after Berserk has begun. He has the lowest health out of all of the Paragons, and Rogues can even tank him for a short time using Evasion!