#crispr ethics

Mixed Nuffield Council Report Too Aspirational on Human Genetic Modification

It’s an odd confluence of events this week that (A) the Nuffield Council, an ethics think tank, gives a thumbs up in a new report to heritable human genetic modification that would probably include using CRISPR in the same week that (B) a new paper reports that CRISPR can cause unpredictable genomic damage and several other concerning reportsabout possible CRISPR technology side effects or…

Editorial Disclosure: This article is an editorial-assisted curated synthesis of verified global coverage. The original source reporting has been analyzed, structured, and compiled by Pune.Media’s Editorial Desk to bring you high-density business insights. Original Coverage & Source Attribution: mezha.net Base editing now edits single DNA bases in human embryos with remarkable accuracy. Ethical…

Big 5 questions anticipating Mitalipov human embryo CRISPR paper

Modified open Wikimedia image

The human embryo CRISPR paper with Shoukhrat Mitalipov as senior author is coming soon.

It will reportedly be focused on the use of CRISPR to genetically modify viable human embryos for reversal of a disease-associated mutation. While strangely press already broke earlyon this paper last week, as much as a week before the paper comes out, and that press suggests very…

In first for U.S., Mitalipov reportedly CRISPR’d human embryos & it was great

More CRISPR’d human embryos, but this time in America?

MIT Tech Review is reporting that Oregon scientist Shoukhrat Mitalipov has used CRISPR on human embryos in his lab in the US. Apparently a paper is in the works on this.

While details are sketchy and some specifics remain to be clarified to be sure of what’s the deal here, this Tech Review report appears generally accurate based on what I’ve…

Paper on 1st use of CRISPR in normal human embryos: problems remain

The first report of the use of CRISPR gene editing in normal human embryos was published today as a short paper from a team in China. There have been rumors for over a year that more CRISPR human embryo papers were coming including some using normal embryos. Here’s one and we can now expect more even as there remain scientific and ethical discussions about this kind of work.

Figure 1b, Tang, et…

Where are all the new CRISPR human embryo papers?

Last year I heard from several sources that there somewhere between 3-5 unpublished manuscripts reporting the use of CRISPR gene targeting in human embryos being shopped around at various journals in addition to the one that had been published. Since that time we’ve seen a grand total of one additional paper reporting on CRISPR of human embryos.

So what gives?

Were the sources wrong?

I don’t…

UC Davis CRISPR Meeting: Big Picture from Ben Hurlbut

The CRISPR meeting has started off wonderfully with a talk by Ben Hurlbut. His talk was entitled, “The Demands of CRISPR’s World: Imagination, Deliberation and Governance”. Since I took notes and listened this post is somewhat freeform.

I liked how Ben asked a lot of questions.

What is “CRISPR’s world” as Science Magazine called it?

How do we want to use the capability of CRISPR?

Ben made a…

Conversation with Kelly Hills: human genetic modification & bioethics

Below is a conversation with bioethics commentator Kelly Hills (who BTW has a great blog), tackling some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable genetic modifications in humans.

I really appreciate her clear and insightful answers to some tough questions that many are grappling with today on this topic.

Part of the possible power of some forms…