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Diagnostica e clinica del C. Difficile alla luce dei nuovi approcci clinico-terapeutici a cura di NewMicro - Network di Microbiologia e virologia del Nord Est
27 settembre 2019 c/o Spazio Ferrari Incontri | Via Ponte di Ravina 15, Trento Evento sottoposto ad accreditamento ECM (provider Fond. Policlinico di Monza)
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کلستریدیوم دیفیسیل و عفونت روده ای کلستریدیوم دیفیسیل یک باکتری از گونه باکتریهای گرم مثبت و اسپور دار است و یکی از علل عفونتهای رودهای بیمارستانی است. سموم کلستریدیوم دیفیسیل در مدفوع ۱۵ تا ۲۵ درصد از بیماران مبتلا به اسهال ناشی از آنتی بیوتیک و بیش از ۹۵ درصد بیماران مبتلا به کولیت غشاء کاذب یافت میشود. بیش از ۹۰ درصد از موارد عفونت به کلستریدیوم دیفیسیل پس از درمان یا در حین درمان با آنتی بیوتیک رخ میدهد. کلیندامایسین، سفالوسپورینها و پنی سیلینها بیشترین آنتی بیوتیکهای مرتبط با عفونت به کلستریدیوم دیفیسیل هستند. #naturesonly #clostridiumdifficile #lactol #probiotic #prebiotic #antibiotic #diarrhea https://www.instagram.com/p/Bt0ZBHaAhF9/?utm_source=ig_tumblr_share&igshid=9b94lc98h88j
Bezlotoxumab (Zinplava)For Prevention of Recurrent C. Difficile Infection
MedicalResearch.com Interview with:
Richard Hengel, MD, FRCPC, FACP Atlanta ID Group MedicalResearch.com: What is the background for this study? How does Bezlotoxumab differ from other medications for recurrent C. difficile infections? Response: Clostridium difficile infection (CDI) is now the most common hospital acquired infection in the United States, accounting for significant morbidity and mortality, not only in the US, but around the world. Despite standard antibiotic therapy targeting the Clostridium difficile bacterium directly, recurrent infection is common, occurring in a quarter to a third of patients, often frail individuals with other concurrent medical problems. These patients can have multiple recurrences leading to their progressive deterioration over time. Until recently, the only treatment for CDI included antibiotics. More recently, fecal microbiota transplant is a promising, but as yet, FDA unapproved therapy. Bezlotoximab is a new FDA approved treatment for recurrent Clostridium difficile infection (rCDI) that compliments standard antibiotics. Bezlotoxumab is a monoclonal antibody targeting toxin B produced by Clostridium difficile during CDI. In two large treatment trials, bezotoxumab, in addition to standard-of-care antibiotics, reduced the frequency of CDI recurrences from about 28% to about 18%. In this study, we set out to see if this new drug performed as well in actual clinical practice as it did in the published clinical trials.
Clostridium difficile CDC image MedicalResearch.com: What are the main findings? Response: Our study shows bezlotoxumab use in real-world settings leads to similar Clostridium difficile infection recurrence rates as those seen in the previously-published clinical trials, where CDI recurrence rates were significantly reduced compared to use of placebo. This also includes patients who are at particularly high risk, including those with three or more risk factors. In addition, patients in the real-world setting encounter significant obstacles to accessing this drug, much of this relating to prompt payor approval and administration of the drug following diagnosis of rCDI. MedicalResearch.com: What should readers take away from your report? Response: Bezlotoxumab appears to be as promising a treatment modality in the real-world setting as in the research setting. However, practicing physicians need be aware of barriers to access, including prompt identification and referral to infusion centers capable of administering the drug, and awareness of payor limitations of drug approval. MedicalResearch.com: What recommendations do you have for future research as a result of this work? Response: Several observations in the course of our study may bear further investigation. Specifically, CDI recurrences appear more common in women than men, in patients with inflammatory bowel disease, and in patients having more than two (versus one or two) prior recurrences. In addition, bezlotoxumab is licensed to be administered during active CDI antibiotic therapy, yet the mechanism of action may not rely on concurrent antibiotic therapy, so this requirement needs to be explored further, such as in the possible use for secondary prophylaxis (after a prior infection that has been successfully treated but in which the patient remains at high risk for a recurrence). MedicalResearch.com: Is there anything else you would like to add? Response: The optimal treatment of CDI, especially CDI recurrences, requires multifactorial, complementary treatment approaches. The mechanism of action of bezlotoxumab complements antibiotic treatment and conceivably other approaches, such as fecal microbiota transplant. I serve as a research advisor to Merck & Co. Inc. Citation: IDWeek2018 Evaluation of Bezlotoxumab in Prevention of Recurrent C. Difficile Infection: A Multicenter Single-Arm Study in Office Infusion Centers The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website. Read the full article
#studiare in modo #studiato 😃🔝 Il #clostridiumdifficile è stato il mio incubo in reparto! . . #koboaura #manualedimalattieinfettive #moroni #malattieinfettive #nursing #nursestudent #nursingstudent #technology #morning #bookblogger #blogger #italianblogger (at Mentana)
