#classic study

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This report is one of a series on the epidemiology of coronary disease. Study of coronary heart-disease suggests that there has been a true increase of it, and that this is not due simply to an increase of coronary atheroma. The atheroma, it seems, is the basic condition of the heart-disease; but other conditions are necessary, and the complex of atheroma, thrombosis, and the capacity of the heart to deal with these in relation the demands med upon it, all need to be studied. Surveys have been made from Social Medicine Research Unit to gain some knowledge of coronary heart-disease as a problem in public health, and in the hope of uncovering social factors which may be favourable or unfavourable to its occurrence. Observations on a group of medical practitioners indicated that such epidemiological study can be carried out with relatively small numbers, and that it may be rewarding. The present report extends this study to other workers and describes the findings among them. Readers are referred to the previous papers where the possibilities and limitations of this type of investigation are considered, and points of theory and method are discussed in some detail.

We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest.