#c. difficile research

Accessible Database for Clostridioides difficile Genome Sequences Supporting Transmission and Epidemics

Martinique Frentrup1​, Zhemin Zhou2​, Matthias Steglich1​,3​, Jan P. Meier-Kolthoff1​, Markus Göker1​, Thomas Riedel1​,3​, Boyke Bunk1​, Cathrin Spröer1​, Jörg Overmann1​,3​,4​, Marion Blaschitz5​, Alexander Indra5​, Lutz von Müller6​, Thomas A. Kohl7​,8​, Stefan Niemann7​,8​, Christian Seyboldt9​, Frank Klawonn10​,11​, Nitin Kumar12​, Trevor D. Lawley12​, Sergio García-Fernández13​,14​, Rafael…

Study Hypothesized Commensal Clostridia are Important for Providing Colonization Resistance Against C. difficile Due to Their Ability to Produce Secondary Bile Acids

ABSTRACT

Clostridioides difficile is one of the leading causes of antibiotic-associated diarrhea.

Gut microbiota-derived secondary bile acids and commensal Clostridia that carry the bile acid-inducible (bai) operon are associated with protection from C. difficile infection (CDI), although the mechanism is not known.

In this study, we hypothesized that commensal Clostridia are important for…

Study of Hospital-Associated Infection – Clostridioides difficile Identified NpmA In the Genome of a Clinical Isolate

Clostridioides difficile: a potential source of NpmA in the clinical environment

Jane W Marsh,1,2 Marissa P Pacey,1,2,3 Chinelo Ezeonwuka,1,2 Sara L Ohm,1,2 Dan Snyder,4 Vaughn S Cooper,4 Lee H Harrison,1,2 Yohei Doi,1,3,5 and Mustapha M Mustapha1,2,3

Aminoglycosides are widely used to treat MDR Gram-negative bacterial infections with bactericidal activity mediated by binding the 16S…

Research Aimed To Identify Bacterial Signatures Associated with Resistance and Susceptibility to C. difficile Colonization (CDC) and C. difficile Infection (CDI)

Authored by Monique J.T. Crobach 1,†,Quinten R. Ducarmon 1,2,†,Elisabeth M. Terveer 1,2,3,Celine Harmanus 1,Ingrid M.J.G. Sanders 1,Kees M. Verduin 4,Ed J. Kuijper 1,2,3 andRomy D. Zwittink 1,2,*1 Experimental Bacteriology, Department of Medical Microbiology, Center for Infectious Diseases, Leiden University Medical Center, 2333ZA Leiden, The Netherlands 2 Center for Microbiome Analyses and…

Biologists Develop Models to Aid Development of Novel Therapies to Fight Clostridioides difficile (C. diff.) Pathogen

The Clostridium difficile pathogen takes its name from the French word for “difficult.” A bacterium that is known to cause symptoms ranging from diarrhea to life-threatening colon damage,

      C. difficile is part of a growing epidemic of concern for the elderly and patients on antibiotics.

Outbreaks of C. difficile-infected cases have progressively increased in Western countries, with 29,000…

DEINOVE Announced Enrollment of First Patient in Phase II Trial Testing DNV3837 in Clostridioides difficile infections

On January 27, 2020, DEINOVE announced the inclusion of the first patient in the Phase II trial testing DNV3837.

  The Phase II clinical trial aims to evaluate the efficacy, safety, and pharmacokinetics of DNV3837 in patients with Clostridioides difficile gastrointestinal infection (CDI).

The trial will be conducted mainly in 15 centers in the United States, in two successive stages:

a cohort…

Researchers Find C. diff. a Major Cause of Nosocomial Diarrheal Disease Exhibits Phenotypic Heterogeneity Within a Clonal Population As a Result of Phase Variation

Recent work has revealed that Clostridioides difficile, a major cause of nosocomial diarrheal disease, exhibits phenotypic heterogeneity within a clonal population as a result of phase variation.

Many C. difficilestrains representing multiple ribotypes develop two colony morphotypes, termed rough and smooth, but the biological implications of this phenomenon have not been explored. Here, we…

C. difficile clade A, Able to Withstand Modern Diet and Healthcare Facilities Long Before They Existed

Researchers at The Wellcome Sanger Institute and the London School of Hygiene & Tropical Medicine say they found that C. diff bacteria appears to have broken off into another species, reports StudyFinds. While the researchers just uncovered the strain, it’s likely been around for tens of thousands of years and is probably the cause of the majority of C.diff infections at hospitals today.

The…