#bone joint

Spondylosis vs. rheumatoid arthritis; meet these “divergent” humoral and cellular patterns

Spondyloarthritides (SpA) refers to a cluster of inflammatory rheumatic diseases with a significant social-economic burden, affecting nearly 1-2% of the Western population. Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2% of the Western population. It is a complex disease with a diverse range of disease manifestations including spinal and…

Osteotroubles shift: porosis focuses on chemokines, arthrosis gets old porosis’ biphosphonates

Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women and one in five men aged over 50 suffer from osteoporotic bone fractures. Osteoporosis is caused by excessive activity of bone resorbing cells, while activity of bone-forming cells is reduced. In healthy individuals, a balanced activity of…

Psoriasis and arthritis in sequence: how PAR1 receptor drives inflammation from surface to the bone

Psoriasis is characterized by red, scaly patches that are itchy and painful; it is chronic, incurable and affects 2% to 3% of the population worldwide. The associated psoriatic arthritis can cause disabling damage to bones and joints. Because that damage also is irreversible, study researchers said it is critical to identify patients with psoriatic arthritis early to prevent further destruction…

Osteoarthritis global burden: numbers on the row, aging fueling below

Osteoarthritis (OA) is a disabling condition that has a significant negative impact on those affected, healthcare services, and the economy. Obesity is a predisposing factor since most MRI studies noticed that a leaner body consititution is positively associated with cartilage thickness. A constant physical exercise is also protective in cartilage degeneration and avoiding smoking may represent a…