#bleomycin

In this article, we will discuss Bleomycin (Distribution). So, let’s get started. Distribution Bleomycin is widely distributed throughout the body with a mean volume of distribution of 17.5 L/m² in patients following a 15 units/m² intravenous bolus dose. Protein binding of bleomycin has not been studied.

In this article, we will discuss Bleomycin (Metabolism). So, let’s get started. Metabolism Bleomycin is inactivated by a cytosolic cysteine proteinase enzyme, bleomycinhydrolase. The enzyme is widely distributed in normal tissues with the exception of theskin and lungs, both targets of bleomycin toxicity. Systemic elimination of the drug byenzymatic degradation is probably only important in…

Bleomycin and Renal Insufficiency

In this article, we will discuss Bleomycin and Renal Insufficiency. So, let’s get started. Bleomycin and Renal Insufficiency Renal insufficiency markedly alters bleomycin elimination. The terminal elimination half-life increases exponentially as the creatinine clearance decreases. Dosing reductions were proposed for patients with creatinine clearance values of <50 mL/min

In this article, we will discuss Bleomycin (Excretion). So, let’s get started. Bleomycin (Excretion)The primary route of elimination is via the kidneys. About 65% of the administeredintravenous dose is excreted in urine within 24 hours. In patients with normal renalfunction, plasma concentrations of bleomycin decline biexponentially with a mean terminal half-life of 2 hours following intravenous…