#bci-540

Coluracetam, purity of substance ≥ 99%, 1000mg

Coluracetam pure chemical available from the racetam family available for purchase online. Coluracetam’s profile is high affinity for Choline.

Coluracetam 1000 mg

Purity ≥ 99%

Net weight: 1 gram

CAS Number : 135463-81-9

Molecular formula: C19H23N3O3

Molecular weight: 341,411 g-mol-1

Form: Powder

Description from English Wikipedia:

Coluracetam (INN; development code BCI-540; formerly MKC-231) is a putative nootropic agent in the racetam family.[1] It contains a chemical group that is a bioisoster of the 9-amino-tetrahydroacridine family. It was originally developed and tested by Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials, it was licensed by BrainCells Inc for research in major depressive disorder (MDD), which was preceded by a "Qualifying Therapeutic Discovery Program Grant" from the state of California. 2] Results from Phase IIa clinical trials suggest that it would be a potential treatment for comorbid MDD with generalized anxiety disorder (GAD).[3] BrainCells Inc is currently [kiedy?] withdrawing the drug for this purpose.[4] [wymagane pełne cytowanie] It may also have potential use in the prevention and treatment of ischemic retinopathy and retinal and optic nerve damage. [wymagane cytowanie medyczne]

Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP) and is considered a potential therapeutic drug for schizophrenia.

Coluracetam increases high-affinity choline uptake (HACU), [6] which is the rate-limiting step in acetylcholine (ACh) synthesis. Studies have shown that coluracetam improves learning impairment after a single oral dose to rats exposed to cholinergic neurotoxins. Subsequent studies have shown that it can produce long-term pro-cognitive effects in cholinergic neurotoxin-treated rats by altering the choline transporter regulatory system.[7]Product for laboratory use only. Not for consumption.

Learn more about Coulracetam from the article in Polish:

https://noopept.us/coluracetam-poprawia-prace-mozgu-lagodzi-stany-depresyjne/