Jan 5
Targeting B7-H3 attenuates uremic vascular calcification by suppressing phenotypic switching of VSMCs and regulating VSMCs-macrophage crosstalk - Research
Objective: This study aimed to investigate the role of B7-H3-an immune checkpoint implicated in inflammation and vascular remodeling-in uremic vascular calcification (UVC), particularly its effects on calcium deposition, vascular smooth muscle cell (VSMC) phenotype, and VSMC-macrophage crosstalk. Methods: An in vitro UVC model was established using β-glycerophosphate (β-GP) treated human…
#attenuates#B7H3#calcification#Crosstalk#doi:10.1007/s10157-025-02811-8#Lan Ding#MEDLINE#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#NIH#NLM#phenotypic#pmid:41484716#PubMed Abstract#regulating#research#suppressing#switching#targeting#uremic#Vascular#VSMCs#VSMCsmacrophage#Xiang Shao#Yansheng Jin
