I think Isaiah's listener is going to die, but not to whatever has been causing their misfortune, I think their going to commit suicide much like Isaiah did. Ofc this is a REALLY dark theory but its one I thought on alot. The entire cause of the listeners issues and near deaths is still pretty up for speculation. Is it a demon? Is it something more, who knows! But its actually rewriting their file, their entire existence and its very obviously putting a strain on Isaiah as he trys to keep them from dying in random ways, well also taking care of his other work; and im sure eventually this will spread to higher Angels as the issues and deaths keep piling up. Isaiah job is both to keep them physically and mentally sound, but knowing that their meer existence is causing immense stress and even possible harm on others definitely isn't doing good to them. I mean they've nearly caused two accidents that could've killed more then just themselves, and even if it truley isn't their fault its still caused by their existence. Eventually whatever is harming them will either get caught or the listener will die, maybe even both, but im willing to bet they've at least debated dying by their own hand at least once by now. They would die entirely of their own choice, no other entities pulling the strings to kill them at random, and they'd lift a major stresser off of Isaiah and maybe even join him in being an angel.
I do believe it would be a last resort kind of situation. They're tired of being reset over and over, and now that theyve met Isaiah they likley remember every time they've nearly died since theyve become roommates so it's definitely been a stresser. This is a dark ass theory but its one I've had for a while!!