Dec 12, 2025
[Antituberculosis.]
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[Antituberculosis.]
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ANTITUBERCULOSIS DRUGS
Isoniazid
• A prodrug and must be activated by a bacterial catalase-peroxidase enzyme that is M. tuberculosis
• The drug is used in combination with other antimycobacterial agents (especially Ethambutol or Rifampin) to reduce the emergence of resistant tubercle bacilli.
• It is rapidly and completely absorbed from the gastrointestinal tract and is part acetylated and in part excreted in the urine.
Isoniazid and Adverse Events-Crimson Publishers
Isoniazid and Adverse Events by Chatue Kamga in Research in Pediatrics & Neonatology
Isoniazid is one first line antituberculosis essential for tuberculosis treatment in paediatric population. Since many years a lot of articles were publicated on adverse events due to Isoniazid. According to WHO and several publication liver injuries is a most important adverse event of Isoniazid. This is a review of literature on side effect induced by INH.
https://crimsonpublishers.com/rpn/fulltext/RPN.000507.php
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For more open access articles in Research in Pediatrics & Neonatology please click on the journal link: https://crimsonpublishers.com/rpn/
A new report of WHO identifies 51 new antibiotics and biologicals in clinical development to treat priority antibiotic-resistant pathogens.
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A new report of WHO identifies 51 new antibiotics and biologicals in clinical development to treat priority antibiotic-resistant pathogens.
Delamanid - an antituberculosis medication for the treatment of multi-drug resistant tuberculosis (MDR-TB) by blocking the manufacture of mycolic acids hence destabilising the bacterial cell wall.