#anthracyclines

Ventricular Repolarization Intervals in Children Previously Treated with Anthracyclines

Anthracyclines - not cell phase specific since they just mix into DNA and inhibit topoisomerase II while making oxygen radicals whenever and wherever they fucking want to...chemotherapy - just hit it hard and fast

Black box warnings 

1: heart toxicity (that’s why we got lifetime doses, so we don’t die of fucking heart failure along with the cancer)

2: secondary malignancy (you’re fucking messing with DNA, which makes a second type of cancer possible)

3: severe myelosuppresion in hepatic dysfunction (uh any cancer drug except for 2 - bleomycin and vincristine!)

4: vesicant (yeah these are pretty toxic) - get them cold compresses and dexrazoxane (Totect) or DMSO 

Contraindications - so if the above are the BBW, I wonder what the fuck will be the CIs....

1: HF/MI/arrhythmias - cus if you already got a bad heart, why the fuck would you take this if it’s gonna mess it up more

2: bone marrow suppression - ANC <1500 (make sure you can calculate this shit); well if you have a shitty immune system, you might die from an infection before the cancer

3: previous usage of anthracyclines - we have fucking lifetime doses, we sure as hell ain’t gonna use it again

4: severe liver impairment - well if you’re immune system’s more likely to be shitty with liver issues, then no don’t take this drug