Conclusions: Inhibition of CETP by anacetrapib and dalcetrapib represents an encouraging development in the management of dyslipidemia, particularly in patients with low HDL-C levels. Results of future trials are much anticipated, as these will clarify the role of anacetrapib and dalcetrapib in reduction of cardiovascular disease.

Testing A New Experimental Drug To Raise Good Cholesterol Level. An tentative pharmaceutical that raises HDL, or "good," cholesterol seems to have passed an first hurdle by proving safe in preliminary trials. Although the trial was primarily designed to aspect at safety, researchers scheduled to present the finding Wednesday at the American Heart Association's annual conclave in Chicago also report that anacetrapib raised HDL cholesterol by 138 percent and abridged LDL, HDL's evil twin, almost in half kala lund gori gand xxx. "We saw very encouraging reductions in clinical events," said Dr Christopher Cannon, advance author of the study, which also appears in the Nov 18, 2010 consequence of the New England Journal of Medicine. A big study to settle the results would take four to five years to complete so the drug is still years away from market who is a cardiologist with Brigham and Women's Hospital in Boston. Other experts are intrigued by the findings, but note that the experimentation is still in very ahead stages full report. "There are a lot of people in the prevention/lipid field that are simultaneously excited and leery," said Dr Howard Weintraub, clinical cicerone of the Center for the Prevention of Cardiovascular Disease at NYU Langone Medical Center in New York City. Added Dr John C LaRosa, president of the State University of New York (SUNY) Downstate Medical Center in New York City: "It's very prefatory but it's foremost because the hindmost drug out of the barrel of this type was not a success. This looks take pleasure in a better drug, but it's not definitive by any means worldmedexpert.com. Don't take this to the bank". LaRosa was referring to torcetrapib, which, adore anacetrapib, belongs to the class of drugs known as cholesterol ester shift protein (CETP) inhibitors. A large trial on torcetrapib was killed after investigators found an increased hazard of death and other cardiovascular outcomes. "I would be more excited about anacetrapib if I hadn't seen what happened to its cousin torcetrapib. Torcetrapib raised HDL astoundingly but that was definitely neutralized by the bourgeon in cardiovascular events". In the new trial, anacetrapib actually showed a tendency toward fewer cardiovascular problems and fewer angioplasty or skirt procedures, although the study only lasted 18 months. It also didn't end in the blood pressure increases that helped doom torcetrapib. To assess the security of the trial, investigators randomly chose 1623 adults with coronary heart disease who were taking cholesterol-lowering statins to meet with either anacetrapib or a placebo for 18 months. At the end of six months, LDL cholesterol was abbreviate 81 milligrams per deciliter (mg/dl) of blood to 45 mg/dl, a reduction of about 40 percent. In the placebo group, LDL levels only declined from 82 mg/dl to 77 mg/dl. Meanwhile, HDL levels increased from 41 mg/dl of blood to 101 mg/dl in the therapy arm, versus a pint-sized spring from 40 mg/dl to 46 mg/dl in the placebo group. "We have 94 percent self-assurance that this drug doesn't have the harmful carry out that torcetrapib had, but we didn't prove a reduction in events," said Brigham and Women's Cannon. "That will be the area of a larger study". Such a study is in the works. Dr Neil Coplan, impresario of clinical cardiology at Lenox Hill Hospital in New York City, stressed that this was a "safety trial, not a endeavour which is saying in any way that people should take these medications nor are the drugs approved". Still "the pilot demonstrated safety and it demonstrated a tremendous effect on altering the lipid silhouette in a good direction. It's very promising but, as the authors note themselves, it's a first step". Experts are still divided as to whether raising HDL levels will truly result in any meaningful improvements in clinical outcomes. "Currently, we're not convinced that manipulation of HDL matters, though certainly it's promising," said Weintraub, who added that results should be ready comparatively soon from other trials exploring the issue. "The truth that LDL was also reduced also makes it promising. We've never been able to satisfactorily demonstrate that raising HDL in point of fact changes risk" vigrxforce.gdn. The only drug currently available to raise HDL is nyacin.

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