2-NBDG: A Fluorescent Tool for Analyzing Cell Metabolism in Metabolic Disorder Studies | GlpBio
2-NBDG, a fluorescent glucose analog, finds frequent application in cellular glucose uptake assessment. It stems from glucose, carrying a fluorescent nitrobenzoxadiazole (NBD) group that simplifies molecule detection and quantification upon cellular entry. This NBD addition doesn't impede the molecule's transportation through the cell membrane via glucose transporters. Once internalized, 2-NBDG can be phosphorylated by hexokinase, a pivotal enzyme in glucose metabolism. By tracking 2-NBDG fluorescence, the pace of glucose uptake in cells can be gauged, furnishing insights into cellular metabolism and potentially revealing targets for addressing metabolic conditions like diabetes.
A Fluorescent Tool for Analyzing Cell Metabolism in Metabolic Disorder Studies, this innovation provides valuable insights into cellular metabolic processes.
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