HOUSE IS AUTISTIC.

They acknowledge it in S3 E4. Wilson heavily suggests to Cuddy that House has Asperger syndrome, but they decide that he can't possibly because he's just a jerk.

Let autistic people be jerks. Let autistic people be assholes WITHOUT USING AUTISM AS AN EXCUSE. IM AN ASSHOLE SOMETIMES. NOT BECAUSE IM AUTISTIC, IM JUST A PRICK. Yes I understand that one of the reasons for him being such a dickhead is because of his leg, he's in pain all the time. But thats even more of a reason to believe that it is a separate issue.

They say that he wants to relate to the kid because then he can get away with being a dick, but he does relate to the kid. He hates change, he thrives on consistency, he needs stimulation or he gets bored and frustrated, he isolates himself- and when he does have to interact, it's with the same people he sees everyday.

House: faggot

Foreman: I.. don't think you should be saying that

Chase: arh naur I theenk he carn archally. Ave you seenim with Wilson?

Cameron: I think it's a little rude to speculate about someone's sexuality while they're in the room

House: oh no no, let Chase continue. I wanna know when he'll start describing how I take in in the ass-

*house realizes something*