Dr Hans Clinics

Exosomes vs Polynucleotides: What Does Your Skin Really Need?

Regenerative aesthetics has become a major trend, with exosomes and polynucleotides increasingly promoted as advanced treatments for healthier, younger-looking skin. But are they the same, and is newer always better?

The answer is no. Exosomes and polynucleotides are different approaches with different biological roles. Exosomes are tiny extracellular vesicles involved in cell-to-cell communication and can carry proteins, lipids and RNA. However, not every product marketed as an “exosome” is the same, as sources, manufacturing methods and levels of characterisation can vary.

Polynucleotides, meanwhile, are DNA-derived molecules used in aesthetic medicine to support skin quality and regeneration. They are increasingly used to address concerns such as skin texture, hydration and elasticity.

The most important point is that neither treatment should be chosen simply because it is trending. Skin concerns differ from person to person. Fine lines, pigmentation, redness, laxity, volume loss and damaged skin may require completely different approaches.

At Dr Hans Clinics, the focus is on understanding the patient before recommending a treatment. A thorough assessment can help determine whether exosomes, polynucleotides or another treatment is more suitable for your individual concerns and goals.

Regenerative aesthetics is an exciting field, but informed decisions matter more than marketing claims. The right treatment isn't always the newest one - it is the treatment that best matches your skin and clinical needs.

Nanofat Treatment London | Microfat Treatment London | Seffiller Treatment London | Fat Transfer London

Nanofat, Microfat & Seffiller: Regenerative Aesthetics Explained

What Are Fat-Based Treatments?

Nanofat, Microfat, and Seffiller are advanced regenerative treatments that use your own fat to restore skin quality, volume, and elasticity. Unlike fillers that simply add volume, these therapies harness stem cells and growth factors naturally present in fat to repair and rejuvenate tissue.

Microfat vs Nanofat

Microfat: Small fat particles injected to restore lost facial volume, improve hollows, and soften wrinkles.

Nanofat: Fat processed into a liquid rich in stem cells, ideal for improving skin texture, scars, and pigmentation.

Seffiller – The Next Step

Seffiller is a refined technique that combines the benefits of microfat and nanofat. It delivers regenerative cells in a controlled way, offering longer-lasting improvements in skin quality and elasticity.

Why Patients Choose These Treatments

Natural and biocompatible (using your own fat).

Improve skin health, not just appearance.

Effective for under-eye hollows, scars, fine lines, and overall rejuvenation.

Key Takeaway

Nanofat, Microfat, and Seffiller represent the closest we have to true regenerative aesthetics. They go beyond surface-level treatments by repairing skin at a cellular level, helping patients achieve natural, long-term results.

If you spend enough time in hair restoration, you start noticing a pattern. A treatment becomes popular, expectations rise, limitations become obvious, and before long a newer version arrives. PRP became widely adopted. PRF followed. Suddenly patients began asking whether PRP was outdated and whether PRF was the future.

The conversation often starts in the wrong place.

One of the things I have learnt from treating hair loss patients is that people become focused on the treatment before they understand the diagnosis. Patients arrive asking for PRP hair restoration or PRF hair treatment when the more important question has not yet been answered: what type of hair loss are we actually dealing with?

Hair loss is not a diagnosis. It is a symptom. Androgenetic alopecia, female pattern hair loss, telogen effluvium, nutritional deficiencies, inflammatory scalp disease and autoimmune conditions can all present with thinning hair. If the diagnosis is wrong, the treatment plan is likely to be wrong as well.

PRP VS PRF IS THEREFORE NOT THE STARTING POINT. THE FOLLICLE IS.

A hair follicle does not usually disappear overnight. In androgenetic alopecia it gradually miniaturises. The hair becomes thinner, shorter and less visible. This process can continue for years. PRP and PRF are attempting to influence follicles that still exist. They are not creating brand-new follicles where none remain.

That distinction is one of the most important lessons I have learnt in clinical practice.

WHAT IS PRP?

PRP stands for Platelet-Rich Plasma. Blood is drawn and processed to concentrate platelets above baseline levels. Platelets contain signalling molecules such as PDGF, VEGF, IGF-1 and TGF-beta. These growth factors are involved in cellular communication, tissue repair and angiogenesis.

The aim of PRP treatment London patients seek is not to magically create hair. The aim is to improve the biological environment surrounding vulnerable follicles.

WHAT IS PRF?

PRF stands for Platelet-Rich Fibrin. Unlike PRP, anticoagulants are generally not used. This allows a fibrin matrix to develop. Advocates of PRF argue that the fibrin scaffold may permit a slower release of growth factors over time.

The concept is biologically plausible. Whether it consistently produces superior clinical outcomes remains less certain.

PRP VS PRF: THE SCIENCE

Much of the debate centres around growth factor delivery. PRP typically delivers a concentrated burst of signalling molecules. PRF may provide a slower release profile because of the fibrin network.

Hair follicles are not passive structures. They communicate constantly with surrounding blood vessels, immune cells, fibroblasts and dermal papilla cells. The dermal papilla is particularly important because it acts as a signalling centre for follicle activity.

VEGF is associated with blood vessel formation. PDGF influences cellular communication and repair. IGF-1 has been linked to maintenance of the growth phase. Wnt/beta-catenin signalling plays a central role in follicular cycling and development. These pathways help explain why platelet-based therapies have attracted attention in hair restoration.

However, biology is rarely as simple as increasing one growth factor and expecting more hair. Human follicles exist within a complex ecosystem. That is one reason outcomes vary.

WHAT I HAVE LEARNT TREATING HAIR LOSS PATIENTS

LESSON ONE: DIAGNOSIS MATTERS MORE THAN TREATMENT SELECTION.

Patients often spend hours researching PRP vs PRF while never investigating why they are losing hair in the first place.

LESSON TWO: EARLIER INTERVENTION USUALLY OUTPERFORMS MORE AGGRESSIVE INTERVENTION.

The patients who tend to do best are often those who seek help while miniaturisation is still occurring. There is more biology left to influence.

LESSON THREE: EXPECTATIONS ARE OFTEN THE BIGGEST DETERMINANT OF SATISFACTION.

Patients expecting a transplant-level result from PRP are frequently disappointed. Patients who understand what the treatment is trying to achieve are usually much happier.

LESSON FOUR: THE TUBE MATTERS LESS THAN THE FOLLICLE.

Clinicians can spend endless hours debating centrifuge settings. Yet a poor candidate remains a poor candidate regardless of preparation method.

WHAT DOES THE EVIDENCE SAY

PRP currently has the larger body of evidence. Multiple systematic reviews and meta-analyses suggest improvements in hair density and hair thickness in selected patients with androgenetic alopecia.

That does not mean every study is perfect. PRP research is notoriously difficult to compare because protocols vary dramatically. Different studies use different centrifuges, spin speeds, platelet concentrations, activation methods and treatment schedules.

IN OTHER WORDS, NOT ALL PRP IS THE SAME.

PRF has a smaller evidence base but an attractive biological rationale. Early studies are encouraging. At present, however, it would be difficult to argue that PRF has definitively replaced PRP.

FEMALE PATTERN HAIR LOSS

Female pattern hair loss deserves special mention because women are often underdiagnosed and undertreated. Many women do not present with a receding hairline. Instead they develop widening of the parting and diffuse thinning.

In selected women, PRP hair restoration can be a useful component of a broader treatment plan. Iron status, thyroid health, nutritional factors and hormonal influences should also be assessed where appropriate.

HAIR TRANSPLANTS AND PLATELET THERAPY

PRP and PRF are not competitors to transplantation. They solve different problems.

A transplant relocates follicles. PRP and PRF attempt to support existing follicles and improve the biological environment. Some surgeons also use platelet-based therapies around the time of transplantation in an attempt to support healing and graft survival.

WHAT WE DO DIFFERENTLY AT DR HANS CLINICS

One thing that has always puzzled me is how frequently patients are sold treatment before receiving a proper diagnosis.

At Dr Hans Clinics, the consultation is often more important than the syringe

The goal is not simply to decide whether somebody should have PRP treatment London patients often enquire about or PRF treatment London patients read about online. The goal is to understand why hair loss is occurring, whether follicles remain viable, what the evidence supports and whether treatment is likely to offer meaningful value.

Sometimes the right answer is PRP.

Sometimes it is PRF.

Sometimes it is medication.

Sometimes it is a transplant referral.

And sometimes it is no treatment at all.

Patients deserve honesty more than they deserve a sales pitch.

WHO SHOULD CONSIDER PRP OR PRF?

Early androgenetic alopecia.

Female pattern hair loss.

Diffuse thinning.

Patients wishing to support transplant outcomes.

Patients seeking non-surgical options.

WHO MAY BE LESS SUITABLE?

Advanced baldness with minimal remaining follicles.

Untreated inflammatory scalp disease.

Incorrectly diagnosed hair loss.

Patients expecting guaranteed regrowth.

FAQS

IS PRF BETTER THAN PRP?

Not necessarily. PRP currently has stronger evidence. PRF has a promising biological rationale.

HOW MANY SESSIONS ARE REQUIRED?

Most patients require a course of treatments followed by maintenance.

CAN PRP REGROW HAIR ON A COMPLETELY BALD SCALP?

Generally no. Results are usually best when follicles remain present.

DOES PRP WORK FOR WOMEN?

Yes, selected women with female pattern hair loss may benefit.

CONCLUSION

The debate around PRP vs PRF often becomes more dramatic than the evidence justifies. Both treatments have a place. Both have limitations. Neither should be viewed as a miracle, and neither should be dismissed outright.

For patients researching PRP treatment London, PRF treatment London, PRP hair restoration or PRF hair treatment, the most important decision is not choosing between acronyms. It is finding a clinician who understands hair loss well enough to determine whether either treatment is appropriate in the first place.

PRP vs PRF : Which Treatment Actually Makes Sense For Hair Loss? - Dr Hans Clinics