How does CBD work? Everything about the effect of cannabidiol
CBD works - whether in the form of oil, drops, liquid or other. So much is certain, but the effect is not fully explored. So you're wondering how CBD works and, above all, how it helps you? The hitherto very positive response from science gives hope for pleasing effects. The mechanism of action of cannabidiol is already described in the literature and that's exactly what we take a look at today. In addition, we betray you, with the CBD effect could be helpful to date.
Cannabidiol and the pleiotropic effect
Pleiotropic - what a word. To say that the CBD is a pleiotropic substance only means that its effects and side effects come about in many different ways. Of course, this does not make it easier for researchers to discover the exact mechanism of action.
However, it is clear that CBD is not psychoactive in comparison to THC and therefore does not cause any changes in consciousness. The cannabidiol effect in the classical sense has nothing to do with the state of intoxication THC is able to trigger. Furthermore, the effects of CBD also promise multiple therapeutic benefits.
CBD effect on different receptors
It is clear that cannabidiol interacts with different receptors - there it either acts actively or merely blocks them. CBD displays a relatively low binding affinity to the "classic" cannabinoid receptors (CB1 and CB2), where THC is effective. Nevertheless, in particular, CB1 plays a not insignificant role.
How CBD works:
CBD works against the CB1 concurrently administered THC and inhibits its side effects (eg cravings & anxiety). In addition, cannabidiol can also act on this receptor... ... CBD inhibits the FAAH enzyme and thus increases the anandamide concentration in the body. Anandamide is an endogenous substance that has a high affinity for the CB1 receptor. At CB2, cannabidiol exerts an effect on the nervous and immune systems by also boosting the concentration of the 2-AG enzyme.
Effect on TRPV-1, a vanilloid receptor
Vanilloid receptor. Reminiscent of vanilla - has something to do with it. The receptor on which our CBD effect unfolds was actually named after the vanilla bean. Just like the pod, cannabidiol stimulates this receptor, which in turn ...
... body temperature, Inflammation and Pain perception. In particular, the CBD effect in headache is explainable because the vanilla bean has been estimated in the past because of just this effect against this type of pain.
Cannabidiol acts directly on the serotonin receptor
Serotonin receptors are a powerful tool in our body that knows how to play cannabidiol. Strictly speaking, it stimulates the 5-HT1A receptor that belongs to this group. This brings out a whole broadside of positive CBD effects:
anxiolytic sleep-promoting pain Against nausea & vomiting hunger control Influencing the addictive behavior Through this cascade of effects, CBD appears to be a potential helper in opiate withdrawal, in the treatment of post-traumatic stress disorder, or in diseases such as Parkinson's disease.
Anxiolytic effect by activation of P1 receptors Among other things, P1 or adenosine receptors regulate the cardiovascular system and release anti-inflammatory substances in the body. By activating these receptors cannabidiol may have a positive effect in this regard.
Ribeiro et al. In 2012, an in vivo study showed that CBD via activation of the adenosine A2A receptor can reduce the inflammation of an injured lung in rats. Another study observed a similar effect of CBD and showed that it is able to reduce pro-inflammatory mediators (Malfait et al., 2000).
In addition, adenosine receptors play a key role in the brain by blocking substances such as dopamine, glutamate, norepinephrine, and acetylcholine. Thus, the CBD effect is able to intervene in this cycle of invigorating neurotransmitters.
Antagonistic effect on the GPR55 receptor
In the course of the Cannabidiol effect, so-called GPR55 receptors can be switched off. These atypical cannabinoid receptors regulate z. As the re-absorption of nutrients from bone into the bloodstream. This effect can stop CBD, which could lead to increased bone stability.
The antagonistic effect of CBD on these receptors may also inhibit the growth of cancer cells, according to recent research by Chinese researchers (G Hu et al., 2010).
There are isolated indications that also the CBD effect on the GPR55 receptor can cause anti-inflammatory effects.
