Chorealis

SHAPE HELL

Deliberate production of informative content designed for spread by word of mouth (like video game teasers): Fine, useful, spreads based on actual appeal.

Submitting products to actually neutral and regulated third parties who evaluate product quality in hopes a product will be elevated and recommended as good: Very useful, noble even.

They tried to kill us, but they did not succeed. And we owe so much thanks to the other oppressed peoples, in particular the Choctaw Nation and the Masai, who sent money and grain to us.

Let me repeat that. The Choctaw Nation who had just gone through the Trail of Tears sent us money to try save Irish lives. It’s led to an understanding between Irish people and Native American tribes, most recently when we donated to the Navajo and Hopi fundraisers for COVID-19 relief, because while it may be a different tribe, Irish people will never forget those who helped us and we’ll help back.

The entire population of the island is less than seven million people. We’re still a million less on this island than pre famine. And it’s not that long ago. My grandmother’s grandparents lived through it. We’ve told the stories, it literally changed the DNA of the country. We have a national fear of renting, because so many people were evicted. People joke about Irish people always offering loads of food, but it’s because there’s that cultural memory of not being able to.

Edit: holy heck it’s real…

My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.

The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.

There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.

So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).

The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.

The phase 1 MS trial is currently active, estimated completion in summer 2024.

I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.

Holy shit. The idea of not having celiac disease anymore is so completely overwhelming.