Valcivir 500mg
DESCRIPTION
Valcivir 500mg includes an active composition like valacyclovir which is pharmacologically classify as nucleoside analogue of viral DNA polymerase prohibitor.
                        Valcivir 500mg
Valcivir 500mg which belongs to synthetically classified as nucleoside analogue. Valcivir 500mg tablet is usually present as prodrug which gets changed into an active molecule known as acyclovir.
INDICATION
The major indication of valacyclovir is used in the condition like; Herpes simplex & herpes zoster In adults Valcivir 500mg is mostly indicated for the treatment of cold sores by Herpes Labialis. Valcivir 500mg have capability to started after the advancement of clinical signs of cold sore has not been evaluated. Valcivir 500mg is likewise determined in the condition like starting scene of genital herpes in immune capable grown -ups. Valcivir 500mg is also indicated in the treatment of relapsed episodes of genital herpes in immuno competent episodes. Valcivir 500mg is exhibit for cutting edge suppressive therapy of repetitive scenes of genital herpes in immuno skillful and HIV-1 contaminated grown-ups. Valcivir 500mg is also used for the contraction of transmission of genital herpes in immuno competent adults. Valcivir 500mg is indicated in the treatment of herpes zoster in immuno competent adults.
                     Valcivir 500mg
In pediatrics In pediatric patients, Valcivir 500mg is includes in the therapy of cold sores with the age of greater or equal to 12 years. Valcivir 500mg is also indicated for the therapy of chicken pox in immuno competent pediatric patients with age of 2 to less than 18 years
PHARMACOLOGY
Valacyclovir which represented as a prodrug that will go through phosphorylation by using viral thymidine kinase enzyme for changing of acyclovir triphosphate, an active metabolite. This active molecule is included in the prevention of herpes viral DNA replication by competitive inhibition of viral DNA polymerase. After injected of this metabolite into the virus &causes terminate of the developing viral DNA chain. Valacyclovir contains; TheDNA synthesis blocked Destabilizing the strand Prevention of new viral growth.
PHARMACOKINETICS
ABSORPTION
After oral intake of Valcivir, valacyclovir is fast absorbed from the gastrointestinal tract and bioavailability by 54.5% plus or minus 9.1%.
DISTRIBUTION
After absorption occurs, the human serum protein binding capacity is 13 to 18%.
METABOLISM
Valacyclovir is rapidly absorbed and approximately 99% of drug get changes into an active form like acyclovir & L-valine by sustaining first pass metabolism & hepatic metabolism by enzymatic hydrolysis.
ELIMINATION
About 89% of radioactivity gets excreted via urine. The medianvalacyclovir half-life period occurs in 2.5 to 3.3 hours.
                    Valcivir 500mg
SIDE EFFECTS
THE MAJOR ADVERSE EFFECTS OF Valcivir ARE
Thrombotic thrombocytopenia purpura/hemolytic uremic syndrome, Acute renal failure, Central nervous effects
THE COMMON SIDE EFFECTS
Low RBC Increased AST Neutropenia Respiratory tract infection Decreased platelet counts Nasopharyngitis Headache Dizziness Nausea Abdominal pain
POST MARKETING EFFECTS
Visual abnormalities Liver enzyme abnormality Hepatitis Renal failure Aplastic anemia Erythema multiforme Alopecia Facial edema High blood pressure Tachycardia Anaphylactic reactions CNS disorders
       Valcivir 500mg
DRUG INTERACTIONS OF VALCIVIR
No drug- drug interactions occurs in the valacyclovir treatment.
CONTRAINDICATIONS OF VALCIVIR
Valcivir 500mg tablet is highly contraindicated in patients with hypersensitivity reactions due to patients are contraindicated to the ingredients of Valcivir.
PREGNANCY & LACTATION
The pregnancy category of valacyclovir is B It should be used with caution. Caution should be taken while administering Valcivir 500mg to nursing woman.
MISSED DOSE
Missed dose condition should be avoided by maintain the regular dosing schedule. Do not skip the dose.
If missed dose condition, patient should be get discuss from the medical practitioner & follow the instructions. Avoid self-medication.
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