#ttx

Some newts living in the western United States are poisonous. Bacteria living on their skin make a powerful paralyzing chemical. It’s called tetrodotoxin (Teh-TROH-doh-TOX-in). These rough-skinned newts appear to borrow the poison to avoid becoming some snake’s lunch.

Scientists Say: Toxin

The toxin, known by the initials TTX, stops nerve cells from sending signals that tell muscles to move. When animals swallow the poison in low doses, it can cause a tingling or numbness. Higher amounts cause paralysis and death. Some newts host enough TTX to kill several people.

This poison is not unique to the newts. Pufferfish have it. So does the blue-ringed octopus, some crabs and starfish, not to mention certain flatworms, frogs and toads. Marine animals, such as the pufferfish don’t make the TTX. They get it from bacteria living in their tissues or by eating toxic prey.

It had been unclear how rough-skinned newts (Taricha granulosa) got their TTX. Indeed, not all members of the species have it. The amphibians don’t appear to pick up the lethal chemical through their diet. And a 2004 study had hinted that the newts didn’t host TTX-making bacteria on their skin. All of this suggested the newts might make TTX.

But TTX is not easy to make, notes Patric Vaelli. He’s a molecular biologist at Harvard University in Cambridge, Mass. It seemed unlikely that newts would make this poison when no other known animal can.  

Vaelli led the new study while he was at Michigan State University in East Lansing. He and his team decided to double check for toxin-making bacteria on the newts’ skin. In the lab, they grew up colonies of bacteria collected from the newts’ skin. Then they screened these germs for TTX.

The researchers found four types of bacteria that make TTX. One group was Pseudomonas (Su-duh-MOH-nus). Other bacteria from this group make TTX in pufferfish, the blue-ringed octopus and sea snails. It turned out that poisonous newts had more Pseudomonas on their skin than did rough-skinned newts from Idaho that aren’t toxic.