#toxicon

Toxicon ready for action

Previously a human from nobility, Toxicon volunteered to get cybernetic upgrades not knowing it would turn into a chemical weapon. Shortly after the enhancements were in place something when haywire causing Toxicon to go berserk. It now lives in a part of the ruins forced into solitude due to it’s malfunctioning poison production. Constantly producing and emitting a toxic airborne virus that attacks the lungs of humans. It only comes to town rarely to get necessities for survival. 

Wanted to draw something, using the old meme, and instead of a suggestion this Book Title came up naturally in conversation. Decided to use the myth and what I knew of 'toxicon' and make it work.

A brilliant release that is both accessible and challenging.

Australian 5-piece Toxicon endeavour to shape the way modern metal will sound going forward with the release of their new album Be the Fire & Wish for The Wind. It will be released on September 2nd, 2022. Showcasing their talents in spates, Toxicon deliver a blistering blast of diverse modern metal with this new album. Where progressive touches, thrashy bursts, groove intensity and more,…

Highlights

•Scorpion venom peptides have anti-carcinogenic properties on breast cancer cells.

•Peptides affect cell cycle, induce apoptosis, and arrest breast cancer cell growth.

•Scorpion venom increases NO and Caspase-3 activity, while MCF-7 is inhibited.

Abstract

Breast cancer is the leading cause of mortality in women worldwide. Today, 1 in 8 women born in the United States will have an invasive cancer in their lifetime. Despite significant attempts, the prognosis of metastatic breast cancer still remains poor. This has compelled scientists to look elsewhere for better therapeutic outcomes. Recent advances in venomic studies have demonstrated some promise in cancer-related ailments. Scorpion venom, a complex cocktail of biogenic amines, proteins, peptides, mucoproteins, organic salts and neurotoxins has shown a potential therapeutic application due to its cytotoxic, apoptogenic, immunosuppressive and antiproliferative properties. This communication reviews the effects of scorpion venom components on breast cancer and their mechanisms.

Keywords

Scorpion venom;

BmHYA1;

Bmk;

Neopladine;

SKBR3;

Caspase;

FasL expression;

BcL-2;

Nitric oxide;

Apoptosis

Corresponding author. Current address: School of Medicine Loma Linda University, Department of Earth & Biological Sciences, 24920 mound street, Loma Linda, CA 92350, United States.

© 2016 Published by Elsevier Ltd.

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Metal Obsession – “We really tried to make something we are proud of” – An Interview With Wayne Clarris (Toxicon)

Here is a sample of the interview conducted by Jake Patton. So Purge is finally out – how has the reception been for it? “It’s been really positive so far and everybody has been jumping onboard. When we first decided to undertake an album as a first release instead of an EP we had a lot of mixed responses with people saying it might be a bit of a risk, but I feel like we have put the extra time…