#saquinavir

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Saquinavir is an antiviral medication used to treat HIV-1. It works by blocking an enzyme needed for the virus to multiply. Saquinavir can interact with other drugs, so it should be used with caution if taken with other medications. It can also increase the QTc interval, which is a measure of electrical activity in the heart. People with pre-existing heart conditions should be especially careful when taking saquinavir. Regular blood tests are recommended when taking saquinavir, as it can increase the risk of diabetes, high cholesterol, and worsen existing liver disease.

Clarithromycin (Biaxin) and ketoconazole (Nizoral) may increase blood concentrations of saquinavir and cause increased severity or frequency of side effects from saquinavir. Saquinavir also increases the concentration of clarithromycin. Rifampin (Rifadin) and rifabutin (Mycobutin) decrease blood concentrations of saquinavir and therefore could decrease the effectiveness of saquinavir. The combination of saquinavir and ritonavir should not be combined with rifampin due to the risk of severe liver damage. When digoxin is taken by patients receiving saquinavir (Invirase) with ritonavir (Norvir), the amount of digoxin (Lanoxin) in the body can increase by 50%, possibly leading to side effects such as potentially fatal rhythm disturbances, nausea, vomiting, and diarrhea, blurred or yellow vision; headache; weakness; dizziness; apathy; confusion; and mental disturbances such as anxiety, depression, delirium, and hallucinations.

Saquinavir will be prescribed for you by a doctor who is a specialist. It belongs to a group of antiretroviral medicines known as protease inhibitors (PIs). It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine.

Saquinavir is used together with ritonavir to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Neither saquinavir nor ritonavir will cure HIV or AIDS.

Saquinavir belongs to a group or class of drugs called protease inhibitors. Saquinavir interferes with an enzyme called protease, which is used by HIV-infected cells to make new viruses. Since saquinavir inhibits, or reduces the activity of this enzyme, this drug causes HIV-infected cells to produce fewer viruses.