Feb 4, 2022
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The ups and downs of transportation within cells
How do cells avoid growing topsy-turvy? Growing so your top, front, bottom and back all wind up on the correct side requires a good sense of direction at the cellular level. A Hiroshima University research group has identified a familiar gene with an unexpected role in directing proteins around the cell.
"The Golgi Body is like a logics center of the cell. Proteins move forward through it like a factory until they reach the distribution centers, which are called the Trans Golgi Network and the Recycling Endosome. We discovered a gene called Rab6 is involved in distinguishing between proteins that can go directly to specific sides of the cell from the Trans Golgi Network and proteins that need to move into the Recycling Endosome before being transported," said Takunori Sato, PhD, a collaborator in Akiko K. Sato's laboratory.
Caption:Transmission electron microscope images of healthy fruit fly eyes (left) and flies with no Rab6 (right). Purple highlight shows the normal space between parts of cells and blue highlight shows the collection of multi-vesicular bodies containing proteins that have been shipped incorrectly from the Golgi body. Image by Yuri Nakamura, Hiroshima University.