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Природа возбуждения буквально будоражит умы веками. Вот только до недавнего времени все способы разгона либидо шли через ЦНС, нагружая и сердце, и кровеносную систему. К счастью, технологии будущего подарили не только повальный доступ к информации, но и педали для получения наслаждений. Один из примеров: пептид PT-141. Рассмотрим, как он работает и чем интересен!
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I just took a dose of pt-141. Let’s see how it goes.
PT-141 Explained: How PT-141 May Enhance Sexual Health
PT-141: An Overview
What is PT-141?
PT-141, also known as Bremelanotide, is a synthetic peptide derived from the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). This peptide belongs to the class of melanocortin receptor agonists and primarily acts on the melanocortin 4 receptor (MC4R) in the central nervous system (CNS). Its molecular formula is C50H68N14O10, with a molecular weight of approximately 1025.2 g/mol.
History and Development
The development of PT-141 began in the early 2000s by Palatin Technologies, Inc., aiming to treat various sexual dysfunctions, including FSAD and ED. Research suggested that melanocortin receptors, especially MC4R, play a significant role in regulating sexual behavior and arousal. The goal was to create a treatment that could offer improved efficacy and fewer side effects compared to existing medications. PT-141 was designed to target the CNS and enhance sexual desire and function by interacting with MC4R and potentially modulating neural pathways and neurotransmitter systems involved in sexual behavior.
Over the years, PT-141 has undergone extensive preclinical and clinical studies to evaluate its safety and efficacy. It remains a subject of ongoing scientific and medical research, with studies exploring its mechanisms of action and potential applications beyond sexual dysfunction.
Primary Benefits of PT-141
Enhanced Sexual Arousal
PT-141 acts as a melanocortin receptor agonist, potentially increasing sexual arousal and desire in individuals with FSAD. By targeting specific neural pathways involved in sexual behavior, PT-141 may improve sexual sensitivity and responsiveness to sexual stimuli, leading to heightened arousal.
Improved Erectile Function
For men with ED, PT-141 has shown promise in clinical studies as a potential treatment to enhance erectile function. By promoting vasodilation in the genital area, PT-141 can increase blood flow to the penis, aiding in achieving and maintaining erections necessary for satisfactory sexual performance.
Localized Action
PT-141's effects are primarily localized to the genital region, minimizing systemic side effects associated with widespread vasodilation. This localized action distinguishes PT-141 from some other medications used to address sexual dysfunctions.
Alternative to Existing Treatments
For individuals who do not respond well to or cannot tolerate other treatments for sexual dysfunctions, PT-141 offers a potential alternative. Its unique mechanism of action sets it apart from medications like phosphodiesterase type 5 (PDE5) inhibitors commonly used for ED.
Psychological Benefits
By enhancing sexual desire and function, PT-141 may positively affect self-esteem and overall sexual satisfaction.
Mechanism of Action
Interaction with Melanocortin Receptors
PT-141 works by stimulating specific melanocortin receptors in the brain, particularly MC4R, which play a key role in regulating sexual function and behavior. Upon administration, PT-141 binds to MC4R, activating downstream signaling pathways.
Increased Blood Flow
PT-141 promotes vasodilation (the dilation of blood vessels) in the genital area, leading to increased blood flow to the penis in men or clitoris in women. This improved blood flow aids in achieving and maintaining erections in men and enhances genital sensitivity in women.
Vasodilation Effect: PT-141 promotes vasodilation, primarily in the genital area, improving blood flow.
Nitric Oxide Release: PT-141 stimulates the release of nitric oxide (NO) in the smooth muscle cells lining the blood vessels. Nitric oxide is a potent vasodilator, causing blood vessels to dilate and further enhancing blood flow to the genital region.
Neurotransmitter Regulation
PT-141 may influence the release of neurotransmitters in the brain, such as dopamine, which is crucial for sexual desire and arousal.
Dopamine Release: PT-141 binds to specific melanocortin receptors, particularly MC4R, leading to the activation of downstream signaling pathways involving various neurotransmitters, including dopamine. Dopamine is linked to the brain's reward and pleasure pathways, associated with feelings of desire and motivation.
Other Neurotransmitters: PT-141's effects on other neurotransmitters, such as serotonin and norepinephrine, could also contribute to its overall impact on sexual function. Serotonin is involved in mood regulation and can influence sexual desire and satisfaction, while norepinephrine, a stress hormone and neurotransmitter, may play a role in sexual response and arousal.
Influence on the Central Nervous System (CNS)
PT-141 acts centrally within the CNS, specifically targeting brain regions associated with sexual arousal and desire. By interacting with MC4R, PT-141 modulates neural signaling and influences pathways associated with sexual function.
Crossing the Blood-Brain Barrier: PT-141 crosses the blood-brain barrier, targeting areas of the brain involved in regulating sexual behavior and arousal.
Neural Circuit Modulation: PT-141 can modulate neural circuits responsible for regulating sexual behavior and arousal, leading to increased excitability and responsiveness to sexual stimuli.
Potential Impact on Libido
PT-141 may directly impact libido and sexual motivation by interacting with specific brain circuits related to sexual behavior.
Neural Events Activation: PT-141 activates neural events that influence libido, primarily through the increase in dopamine release.
HPG Axis Influence: PT-141 may impact the hypothalamic-pituitary-gonadal (HPG) axis, which regulates sex hormone production. Although PT-141 is not a direct hormonal treatment, its influence on this axis could have secondary effects on hormones like testosterone and estrogen, further contributing to its potential impact on libido.
Conclusion
PT-141, also known as Bremelanotide, has been extensively investigated as a potential treatment for both FSAD and ED. As a melanocortin receptor agonist, PT-141 targets specific neural pathways involved in sexual arousal and desire. In women with FSAD, PT-141 may enhance sexual sensitivity and increase sexual motivation by promoting vasodilation in the genital area, leading to increased blood flow and improved genital sensitivity. For men with ED, PT-141's mechanism of action involves enhancing blood flow to the penis by promoting vasodilation in the genital region. This increased blood flow may help in achieving and maintaining erections, which is essential for satisfactory sexual performance. Ongoing research will continue to shed light on its efficacy and applications, providing further insights into its role in enhancing sexual health and well-being.
What is PT-141? Discover it’s amazing benefits for sexual dysfunction
What is the effect of peptide PT-141?
Pt-141 is unlike any other drug sold! This new prescription for sexual dysfunction is brain-based. It produced a response in most women and men that can only be described as magical.
M: Remarkable! Looking and feeling fuller, thicker and sturdier will make you feel like you've stepped into a time machine. Experience multi-day reactions. It can bring back the energy you thought you'd lost forever.
ED affects nearly 20 million men in the United States. Many people are not all old men, as is commonly believed. According to one study, erectile dysfunction affects a quarter of the male population under the age of 40. Pt-141 is the answer many men have been looking for!
Female: It's a game changer. There are not many options to help lose the desire for intimacy. The PT-141 is a brain-based product unlike anything made to date! It heightens your desire and helps connect with your partner. Pt-141 provides youthful emotional response.
Pt-141 empowers our female patients by restoring libido! A third of the population has experienced sexual dysfunction, according to a 2015 survey. Among older premenopausal women, about 6 million suffer from hypoactive sexual desire disorder (HSDD). If you happen to be someone in one of these pools, you're clearly not alone. Our peptide PT-141 may be the answer you are looking for.
How exciting is that? Pt-141 is a drug that helps increase your libido, body engagement and performance, and is unique on the market. AIM has the purest form of peptide pharmacy manufactured for the end result.
What is pT-141? Pt-141 is a previous development code name for Bremelanotide. This is a peptide originally developed as a tanning agent. It is a hormone that stimulates melanocytes (MSH) and can affect sexual arousal, helping to increase sexual desire levels and penile erection. Unlike Viagra or Cialis, PT-141 is not a PDES inhibitor and does not target the vascular system. Instead, it acts on the nervous system by activating neurons in the hypothalamus to increase libido.
How was PT-141 discovered? The discovery of PT-141 as a sexual activity enhancer came about by accident, thanks to the generous volunteer service of scientist Mac Hadley, who was experimenting on his own body and ended up with an eight-hour erection. During the earliest tests, a double dose of the earlier compound, Melanotan II. The alpha-MSH test was first performed on rats in the 1960s and developed into the 1980s. Melanocortin is a peptide hormone responsible for regulating many physiological functions. Melanotan ANALOGUE, Melanotan I, was tested as a tanning agent and Melanotan II as a sexual dysfunction agent.
Buy PT 141
PT-141 10MG, also called the libido drug, is quite popular among researchers and scientists alike. Studies have shown that this peptide is essentially beneficial in restructuring the libidinous system. Also known as Bremelanotide it has been under experimentation for various studies. Scientists have claimed that they produce results when subjected to erectile dysfunction in mammalians. They have also been seen to be useful in female arousal dysfunction, vaginal artery smoothness and disorders related to vaginal walls. However they may or may not be limited to such areas itself which is why further studies have been going on related to this peptide. At Pinnacle Peptides you will find PT-141 in vials of 10MG simply for research purposes and not for average human intake. Buy PT-141 10MG in its purest form from Pinnacle Peptides and be ensured of a high rate of success in all your experiments Pinnacle Peptides offers you the best range of these peptides. The quality of the products is credible and trusted by many scientists all over the world. You can buy them in single vials or order them in bulk as per your research requirements. They are easily availed while all you have to do is just select and order online, and have them delivered at your doorstep .If you are a non resident of USA, you do not have to worry, because even then you can have them delivered at your place, since international deliveries are made as well. PT-141 10MG when subjected to premenopausal women who have hypoactive sexual desires, yields positive results related to sexual functioning. This peptide even works well for men who have erectile dysfunction or impotence disorder. This is why this peptide seems to work well for both men and women who have less than average sexual disorder. Further research has been going on regarding this peptide to study its usefulness. However you must not directly intake these peptides without a doctor’s prescription. The difference between PT-141 10MG and other drugs such as Viagra is that it does not act directly upon the vascular system but yet manages to enhance the sexual urges on intake. If you want to purchase this item for your research, you might as well get in touch with the online source, Pinnacle Peptides and avail them for research and/or medicinal uses. The products we offer are intended for laboratory research use only. In purchasing any of these items, the customer acknowledges that there are risks involved with consumption or distribution of these products. These chemicals are NOT intended to use as food additives, drugs, cosmetics, household chemicals or other inappropriate applications. The listing of a material on this site does not constitute a license to its use in infringement of any patent. All of the products will be handled only by qualified and properly trained professionals. All customers represent and warrant that through their own review and study that they are fully aware and knowledgeable about the following: Government regulations regarding the use of and exposure to all products. The health and safety hazards associated with the handling of the products they purchase. The necessity of adequately warning of the health and safety hazards associated with any products. Pinnacle Peptides and www.pinnaclepeptides.com reserves the right to limit and/or deny sales of products to any unqualified individuals if we have reason to believe that misuse will occur.
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Product Name: PT-141 Synonyms: Bremelanotide, PT-141 Acetate CAS #: 189691-06-3 Molecular Formula: C50H68N14O10 Molecular Mass: 1025.2 Da (g/mol) Amino Acid Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH Purity PT-141 has a peptide purity level that exceeds 99.0% as determined by HPLC and MS. This peptide was synthesized with no additives and is supplied as a white lyophilized (freeze-dried) powder. Usage Bremelanotide, similarly to its analogues -MSH and melanotan II, acts as a non-selective agonist of all of the melanocortin receptors except MC2, where it lacks significant affinity. Reported activity of the drug is as follows: MC1 (Ki = 0.68 nM) MC2 (Ki > 1000 nM) MC3 (Ki = 72.07 nM) MC4 (Ki = 19.25 nM) MC5 (Ki = 166.8 nM) Bremelanotide appears to stimulate sexual desire and arousal completely or mostly via activation of the MC4 receptor (the MC3 receptor may also be involved). It modulates inflammation and limits ischemia via activation of the MC1 and MC4 receptors. According to Palatin Technologies' original 2003 patent for bremelanotide, it possesses approximately 50 times the potency of melanotan II as an inducer of erection in male rats. In addition, it was stated in the patent that the therapeutic window of bremelanotide in animals (specifically, the range of induction of the desired sexual arousal relative to the induction of side effects including nausea, yawning, stretching, and decreased appetite) was >1,000-fold, whereas that of melanotan II was only 3- to 4-fold. They concluded that bremelanotide would be more tolerable than melanotan II.
PT-141, as an erectile dysfunction solution, is liked by men who want to bring back the fire into their sex life. For sale at our peptide website.
Bremelanotide PT-141 for Sex Enhancer
Bremelanotide; PT-141
Cas No.:32780-32-8 Molecular Formula:C50H68N14O10 Molecular Weight:1025.2 Purity (HPLC):98.0%min. Single Impurity (HPLC):1.0%max Amino Acid Composition:About 10% of theoretical Peptide Content (N%):80.0% min. Water Content(Karl Fischer):6.0%max. Acetate Content (HPIC):15.0%max. MS(ESI):Consistent Mass Balance:95.0~105.0% Appearance:White powder
PT-141 Description
PT-141…
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