#protein aggregation

Binder design using sequence input RFdiffusion For each target, approximately 10,000–50,000 diffused designs were generated given only sequence input of the target using RFdiffusion (v1.1.0). The resulting library of backbones were sequence designed using ProteinMPNN (v1.0.1)24, followed by AF2 + initial guess26. Initial guess is the protocol in which the protein structure provided to the model…

Biophysical Studies of Protein Aggregation In Germany

University of Düsseldorf invites applications for a PhD position in Biophysical studies of protein aggregation. This position is available for a period of three years starting from October 2015. Highly motivated candidate with a background and/or interest in Physical Chemistry and Biophysics can apply for this position. The successful candidate will be mainly based at the Institute of…

Physicists push new Parkinson's treatment toward clinical trials

Research at Michigan State University, published in the Journal of Biological Chemistry, shows that a small "molecular tweezer" keeps proteins from clumping, or aggregating, the first step of neurological disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease.

S. Acharya, B. M. Safaie, P. Wongkongkathep, M. I. Ivanova, A. Attar, F.-G. Klarner, T. Schrader, J. A. Loo, G. Bitan, L. J. Lapidus. Molecular Basis for Preventing  -Synuclein Aggregation by a Molecular Tweezer. Journal of Biological Chemistry, 2014; 289 (15): 10727 DOI: 10.1074/jbc.M113.524520