#project violet

Project Violet

Finally Done  _(:3 」∠)_

I’m really happy with how this turned out , a lot of changes was made. She is looking much more like the way I’d Imagine her. A “Happy Go Lucky” and also  Athletic Personality.

Project Violet

WIP’z

Sketchtember Day 10

Decided to look into my OC , Violet. And see what can I improve on her design :3

3rd Iteration of my Cyborg OC made recently

I’m happy with how this Iteration turned out and will probably settle with this design. Minor changes are likely to happen :3

I’ll call her , Violet

These two fics are the ones responsible for me shipping Red Swan Queen. I guess some could take a look at both of them and say "but of course you like them, you're a guy and these fics are super smutty". And it's partly true, because, what there is not to like about the sexy bits.

But if you only focus on the sex, you're missing too much of the actual story. I loved Ruby in these fics, she incredibly tired of her inability to satisfy her sex drive, but she's able to control herself and function somewhat normally.

She approaches Emma in a very calmed but direct way, telling her what she needs, never demanding and always respecting her. She never expects Emma to do something she's not comfortable with.

And she also takes the opportunity to set up the perfect way to bring Emma and Regina together. She knows they have it bad for the other, but can't stand to see them like this. She also makes it clear she would like to partake in the mind blowing, amazing sex the sheriff and the mayor are bound to have. But even so, her heart is in the right place, and their happiness is more important than her need.

She eventually gets to share their bed, and it's done in a very believable way, with Regina already being all jealous of their past relationship, even when it was purely physical. She's not very sure about herself and fears that she would lose Emma or that she'll have to fight for her. And that first time, when she only lets her see and not touch, hot damn!!!

Those are some of the reasons I love these two fanfics, but it's the last scene, and particularly the last lines that made laugh so hard, that made me love them. I'm talking about when Snow talks to Ruby about how she knows that there's some kind of deal between Emma, Regina and Ruby, and says:

"Make sure they are ok, Red. Let me know if I can help them somehow, but just don't give me any details on what the three of you get up to. I just couldn't stand all the… porn."

When I read it I couldn't believe it, that you had put that in the fic, and in such a funny and brilliant way. A laugh so hard my back, my stomach and my head hurt. I just love this, so much.

And I also love all your other fics I've read, but for this occasion I'm supposed to only talk about these two, which I picked for the reason that they were the first fics I read from you and also because they were the first Red Swan Queen fanfics I've ever read, even when it's not romantic RSQ.

https://www.youtube.com/watch?v=edM6rZuyxtc OK Sweetheart is helping to raise $100,000 for cutting edge research on cancer and rare diseases with their new song “Safe”. The music video features family members of loved ones who have battled these terrible diseases. Each view of the video equates to a $1 donation toward research.Project Violet Ok Sweetheart

Alright guys.

As some of you may know, my sister suffered from pediatric brain cancer when she was 7, we have no idea what caused the cancer to grow, but she almost died and was treated and (obviously) survived, much thanks to the wonderful team of brain surgeons at Seattle Children's Hospital. 

Dr. Jim Olson was one of her surgeons, and not only does he work with children of all ages at the hospital, he is making incredible discoveries at Fred Hutch, one of our cancer research labs. 

Dr. Olson and his partner created a revolutionary drug that literally lights up cancer cells so that surgeons can remove only infected areas, which eliminates the chance of damaging tissues, especially in the brain. Their "Tumor Paint" starts human trials really soon and what is even cooler? The drug is based off of venom from the Israeli Death Scorpion.

They are literally using venom to aid cancer treatment.

They are now developing a new class of anti-cancer compounds: molecules engineered to attack cancer cells without harming the healthy cells around them. These new compounds, called optides, could dramatically improve on traditional chemotherapies. And their approach is potentially less expensive and more powerful than other next-generation techniques. Optides address one of cancer treatment's most vexing problems: chemotherapies usually destroy healthy tissue alongside the cancerous cells they target. This can exact a heavy toll on patients, with many suffering such severe side effects that they must limit their chemotherapy dosage or stop treatment early. In contrast, optide molecules can be better instructed to bind to particular kinds of cancer cells, disabling only those cells. This innovative research uses nature as its guide. Many organisms produce tiny proteins, called peptides, that are small enough, stable enough and specific enough to deliver cancer drugs. The team modifies these molecules to generate versions that zero in on cancer cells. They're basically using nature to cure cancer. 

You can check out this HELLA cool project and "adopt" a drug candidate here: https://www.projectviolet.org/adopt

What is really important is that there is a collection of music that was made to sell in support of Project Violet, and one of those songs was put on youtube a while ago. 

An extremely generous family said that they would give $1 for every single view that this video gets. They are willing to donate $100,000 to this wonderful cause. 

You can watch the video here: http://projectviolet.us3.list-manage.com/track/click?u=c50b0ff24764dad38625c3d42&id=47b380dd5e&e=34ae4ca40d

‘Project Violet’ aims to speed drug discovery using scaffolds from nature and crowdfunding

Dr. Jim Olson, a pediatric brain cancer specialist whose laboratory is based in the Clinical Research Division at Fred Hutch

Photo by Susie Fitzhugh

SEATTLE – Aug. 12, 2013 – A spirited, red-headed girl named Violet who died at age 11 from an inoperable brainstem tumor is the inspiration behind “Project Violet,” a “citizen science” drug-discovery project being launched by Fred Hutchinson Cancer Research Center.

The project is using crowdfunding to enlist the help of the community to develop a fundamentally new class of anti-cancer compounds derived from scaffolds of nature – chemical templates from organisms such as violets, scorpions and sunflowers – to attack cancer cells while leaving healthy cells untouched. The ultimate goal is to develop highly targeted treatments that kill the cancer while sparing patients from the toxic side effects of chemotherapy such as hair loss and nausea.

The visionary behind the project is Violet’s doctor, Jim Olson, M.D., Ph.D., a pediatric brain cancer specialist whose laboratory is based in the Clinical Research Division at Fred Hutch and who also practices at Seattle Children’s.

Before Violet died last year, she and her family requested a rapid autopsy to enable the creation of important research tools from her brain tumor. She wanted those tools to be shared with scientists worldwide to help kids who are diagnosed in the future.

‘The most exciting project I’ve worked on in my life’

“That spirit of generosity led to the most exciting scientific project I’ve worked on in my life. It was only fitting that it be named after Violet,” Olson said.

“That spirit of generosity led to the most exciting scientific project I’ve worked on in my life. It was only fitting that it be named after Violet,” Olson said. “I knew that we were going to do this in her spirit, memory and honor.”

Project Violet was built on the success of Olson’s initial invention of Tumor Paint, a molecule derived from scorpion venom that safely travels through the body and causes cancer cells to light up to help surgeons visually distinguish cancer from normal tissue.

“We were impressed that scorpions have evolved amazing drugs, which led us to begin looking deeply into the drugs produced by other plants and animals. For example, sunflower petals are not eaten by bugs because they make a compound that protects them from hungry insects,” Olson said. “Likewise, we found exquisite examples of drugs made by potatoes, spiders, cone snails, sea slugs and, yes, violets.”

Optides: Creating precision therapies that spare healthy cells

Inspired by nature’s medicine chest, Olson and colleagues created an entirely new class of drugs: “optimized peptides” or “optides” for short. These tiny molecules can be instructed to bind to particular kinds of cancer cells, disabling only those cells. They also can be attached to chemotherapy drugs, transforming them into precision therapies that spare healthy cells. Optides are also potentially less expensive and more powerful than other next-generation therapies.

Olson and colleagues are developing optides that target some of the most treatment-resistant malignancies: brain cancer, melanoma, breast cancer and tumors of the neck and throat.

While developing new cancer treatments is the primary focus of optides research at Fred Hutch, this new class of drugs also offers the potential to develop new treatments for epilepsy, depression, anxiety and other disorders of the central nervous system, Olson said.

“Optides offer unprecedented accuracy – an entirely new class of drugs that are far less toxic, far more effective and flexible enough to be used in a wide range of applications,” he said.

Using scaffolds from nature to develop drugs is not a new concept; other researchers and drug companies have been interested in creating new drugs using molecules derived from plants and animals. However, most efforts have failed because there have been huge barriers to making thousands of optide variants inexpensively, rapidly and in quantities large enough to conduct scientifically rigorous experiments.

“Our team at the Hutch has overcome six major barriers,” Olson said. He and his collaborators have developed a new optide production system to quickly synthesize thousands of optide variants that can then be evaluated for therapeutic potential.

“Whereas it takes some companies a decade to make hundreds of peptide drug candidates, we can make 12,000 a month and are ramping up beyond that.

“Nature provides the raw materials and we provide the expertise to turn them into lifesaving therapies,” Olson said.

How the public can get involved

Citizen scientists all over the world can help build Project Violet’s candidate drug libraries by adopting a drug candidate for $100. By choosing from one of six organisms – violet, scorpion, locust, sunflower, spider or human – they’ll also receive an image of their drug molecule.

The drug candidates will be tested by Fred Hutch scientists for lifesaving properties. If the drug candidate fails at any point, it can be replaced with a new one so the citizen scientist always has a “horse in the race.”

A drug that shows promise will advance to additional testing with the goal of being evaluated in human clinical trials.

For more information, visit www.projectviolet.org, email [email protected] or visit Project Violet’sFacebook page.

To view Olson’s recent TEDxSeattle talk about Project Violet, click here.