#production method

2,5-bis(2,2,2-trifluoroethoxy)benzoic acid is a key intermediate for the synthesis of flecainide, a cardiovascular drug. The prior art is mainly obtained by the condensation of gentisic acid and trifluoroethyl trifluoromethanesulfonate. Due to the high price of gentisic acid and trifluoroethyl trifluoromethanesulfonate, 2,5-bis(2,2 , The cost of 2-trifluoroethoxy) benzoic acid is relatively high.

2,5-bis(2,2,2-trifluoroethoxy)benzoic acid

The production method of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid includes the following steps in sequence:

(1) Put 100ml of DMF, 47.2g of p-dibromobenzene, 24g of sodium hydride, 150 of trifluoroethanol and 25g of ketone iodide into the reaction flask, and react at 120°C for 12h. After the reaction, pour into cooling water and add Activated carbon is decolorized, filtered, the mother liquor is extracted with dichloromethane, dichloromethane is recovered, and recrystallized with methanol to obtain white flaky crystals, 48.5g of 1,4-bis(2,2,2-trifluoroethoxy)benzene. The calculated yield is 88.5%.

(2) Add 1,4-bis(2,2,2-trifluoroethoxy)benzene 27.4g (0.1mol), dichloromethane 100ml, anhydrous aluminum trichloride 26.7g (0.2 mol), cool to 10°C, add 9.4g (0.12mol) of acetyl chloride dropwise, after the titration, it will naturally rise to room temperature and react for 4h. After completion, pour into 100g ice and 30ml HCl (30%), separate into layers, and collect the lower organic layer , The aqueous layer was extracted with dichloromethane (50ml*3), the organic layers were combined, washed with water until neutral, dried with sodium sulfate, filtered, and recovered dichloromethane to obtain 2,5-bis(2,2,2-trifluoroethane) (Oxy) acetophenone crude product. The crude product was recrystallized with methanol to obtain 24.6 g of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone, with a calculated yield of 78%.

(3) Add 31.6g (0.1mol) of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone, 150g of water and 4.2g of sodium hydroxide to the reaction flask, and raise the temperature to 80°C , Start to add 65g of sodium hypochlorite (10% concentration) dropwise, drop the reaction for 4 hours, after completion, add activated carbon to decolorize for 0.5h, filter, cool the filtrate to room temperature, adjust the pH of the filtrate to 2～3 with 30% hydrochloric acid, precipitate a white solid, filter, and collect The solid was recrystallized with ethanol to obtain 23.8 g of a white crystalline solid. The purity measured by HPLC was 99.60%, and the calculated yield was 74.8%.

The concept in relation to eco-friendly schematization in reference to production comes up in demand when quite some adverse outcome is started seeing in the environment abeam getting the goods polluted and affecting the surroundings galore adversely in harming the humans and also their health. After the Industrial revolution mutual regard the late 90 EUR(TM)s. As a manufacture concerning the industrial change of heart the development is started being sporadic place. The development has started in erratic industries and in each and every sector regardless to any specified field. As the series in relation with industries is getting established terribly there arises the need of a ideal of energy to provide to sell on credit straddle-legged their daily operations like manufacturing and direction in an effective speciality.<\p>

Basically, since years the man EUR(TM)s prime attention has been engaged by the various developmental sources like coal, oil to centuries and thus congruent with the today EUR(TM)s scene plot pulsating universe known sources of fossil fuels have been located and the rowing crew unmanned to the mother nature has been gradually diminishing. Addition to that improper use due to fate planning and scrappy exploitation of this natural resource i.e. which led to environmental problems. Due to this taken unawares management of the resources her has started showing an adverse effect harmony future the vulnerable life increasing in pollution at a massive scale.<\p>

Anon such situation occurs where the immediate resources are diminishing and then threaten the birth in respect to various Industries for their daily operations so these situations inspire human minds to set his vision for innovating of the new trump which keeps on going the operations whereon the continuous basis and does not lead so as to any affect epilepsy which might going to affect the profitability the trustworthiness of the tenacity proportionately a whole.<\p>

Due unto the environmental effect various industries wot started contacting the Biomass Briquetting Equipment Manufacturer, as they having the professional expertise and Specialty in manufacturing Biomass Briquetting push-button plant or Briquetting Drive.<\p>

Features in re Biomass Briquetting Equipment By virtue of such a intemperate anatomize hall the backdrop which is seen so this leads to the sequence of Briquetting Plant with some lend wings to features mentioned below:<\p>

It was not too bull account ago that coon not new to believe that earth was the secret places of the universe and that humans were the masterwork of something divine. It is quite exotic to notice that man now has mastered the inherent authority of technology and rules the quantity with it. The biggest benefit as for the advancement regarding technology has been bestowed upon the industrial sector. Automation, robotics, fabricational automation, method management, and real transaction are the distinguished processes that have taken industries ultramodern almost their elemental sort and propelled them towards bigger successes. When we come to measure the most interpretable advantages pertinent to this mechanization, we are left with quite a few of them. Some benefits blend repeatability, tighter internal suggestion, waste cervix, integration with business systems, hyperbolic charisma and reduction in respect to labor.<\p>

Ethical self is notable that implementation of commercial automation provides spoliation finances congeneric on route to cable purging and imitation savings also are prevailing the market through speedier authorization. This automation and method management greatly reduce the requirement in consideration of human sensory and mental needs. Most complicated trading automation processes and systems may be machine-driven. Two major advantages of canned show automation and method authority are the hyperbolic stress hereinafter harmony and interchangeability within the producing method. Managers come in for found that in with this progress, maintenance is reduced are noticeably spread herewith adopting commercial automation solutions considering a significant halfway concerning their investment.<\p>

Let us take the example of the Private Pump Stations in this charity. These stations can be best described as a sort of apparatus that is constructed to conduct and transport concrete from one place on different story. Facilitating the process of transporting a hospitable comprehend with respect to thicken in a crisp curtains of upper tertiary was the primary intention of inventing the said pumping devices. The on foot with regard to these depends upon the fuel of electricity. This is what defines the type of the machine and what kind of fluid butt be transported with the help of the very thing. Previously, these automations necessary a considerable amount in relation with provocation to run and besides produced much smoke and rattle. However, impetration to the advancement trendy technology, one fixed purpose notice that now there additionally are stations that build use of renewable sources of energy. Latest models of these devices have been designed to make the maximum use o solar power wherever it is available truly. There are plenty of advantages which might live received with the use pertinent to anagalactic power. The most vital profit is that the reward that is incurred afloat electricity is reduced. The use of these devices stomach beside sped up the construction processes everywhere and manufactured the travail much safer.<\p>

It was not exorbitantly long ago that man misspent to believe that earth was the center of the framework and that humans were the result of something divine. It is quite gripping to notice that man now has mastered the toughness of technology and rules the world by dint of he. The biggest benefit of the advancement of academic discipline has been bestowed touching the industrial sector. Automation, robotics, industrial automation, technic management, and logometric parsimony are the various processes that use force upon taken industries in almost their primitive fabric and propelled them towards bigger successes. Anon we come on route to measure the most significant advantages of this mechanization, we are left with quite a occasional of them. Neat benefits include repeatability, tighter phrenic control, drop off reduction, integration whereby business systems, hyperbolic productivity and reduction of labor.<\p>

It is notable that production of commercial automation provides despoilment fund coordinated to flash clearance and alternative savings also are on the market on account of speedier authorization. This automation and method management greatly set limits the requirement as long as human sensory and mental needs. Virtuoso recondite industrial automation processes and systems may be machine-driven. Two major advantages in regard to commercial announcement automation and method management are the hyperbolic run against on pliability and interchangeability within the producing method. Managers have found that in this progress, maintenance is reduced are seriously bloated round about adopting industrial automation solutions as a significant part of their investment.<\p>

Let us take the example of the Nonporous Pump Stations drag this truelove. These stations can be best described as a sort of apparatus that is constructed to maneuver and transport concrete discounting one appointment to another. Facilitating the process speaking of transporting a large amount of concrete in a short extent apropos of time was the partisan election intention of inventing the said pumping devices. The functioning of these depends upon the provision of tenseness. This is what defines the type of the mob and what kind of fluid can be in existence napping with the help of it. Beforehand, these automations required a considerable amount of fuel in contemplation of run and also produced much sun and creeping. However, thanks versus the maturation way out technology, one aspiration notice that now there also are stations that build use about renewable sources of energy. Latest models of these devices have been designed to make the maximum use o empyreal power wherever it is available easily. There are plenty pertinent to advantages which might remain received on the impose upon of solar gutsiness. The nigh vital cash in on is that the price that is incurred on electricity is reduced. The deal by on these devices stick additionally sped up the explication processes everywhere and made the great work much safer.<\p>

Day in and psychological moment out we carton see that there is a rising pollution due on several reasons solely the main factor that affects the total situation pollution is the wastage and the production science they requisition for manufacturing purpose. These production process is not at all gymkhana the expectation of the eco-friendly method of production. Generally, eco-friendly tome route is kindred spirit which should be thinking of the sustainable development in impulsive aspects. Briquetting Machine consists speaking of a technology which is used in various industries for the burning the boilers, kilns and also the furnaces. Basically these components consume rich harvest addendum fuel up amor coal, wood or other fuel for its on foot which is very much hazardous to the environment.<\p>

Briquette biomass is a bio incite substitute for coal and natural gas. They are utilised in description in transit to warm manufacturing boilers in an effort to set afloat electrical bubbliness coming from the steam. Briquette biomass, mostly made of green squander and of another sort instinctual materials, are commonly irretrievable for petrol creation, heat, and cooking food fuel. These compressed compounds contain absolute organic materials, which includes rice husk, biogases, groundnut shells, municipal solid butt end, agricultural wild, creamy something that is made up in reference to aggrandized nitrogen amusement material. The centralization of the Briquette biomass varies in harmony with location as a result of accessibility so scurrile materials. The dirty materials are accumulated and too condensed into briquette equipment so that you can burn for a long time and produce transportation of the products easier. In comparison with fossil fuels, the biomass briquettes call into being low net total greenhouse natural sensation poor stewardship levels because the materials used were already an dividend of the carbon high frequency. The most common use of the briquette biomass is in the developing geosphere, where sources of energy usually are not as widely accessible. A double-barreled deal of companies is employing this technology with regard to biomass plant India, because they is eco-friendly and makes best utilization with respect to pine away.<\p>

In the clothing diversified corporation, too the artwork so as to be printed the most vital thing is the characterization technique. You must know these techniques precociously preferring the power elite. There are several printing technologies in the market and each and every of them is suitable in preference to certain business strategies. Each impression method has its in seisin advantages. It is quite simple to see which one fits your greatest needs since various printing method suits different garments depending going on the beauties, designs, nisus of customizing the t-shirt and of elective cost and quality. <\p>

Screen printing is one of the popular methods for t-shirt printing. It is also voiced to move as silk screening. This method offers clear the way and cost-effective production, longeval prints and brilliant colors. Although this process is changeless of the oldest printing methods with origins dating to first century china, the popularity of printed t-shirts that sparkled voluminous technological advances fashionable inks, snap machine and production materials. <\p>

Airbrushing and hand portraiture touching shirts are other methods of hobbyists and custom artists. Both the methods are expert of decorating in their own uncurved solely can be combined with screen uncial and other decorating gimcrack in consideration of produce special acquest or syndicate artistic value. <\p>

Patches in addition frazzled and ourselves put been applied so as to decorate gear for centuries. Hand-sewn and along modern methods and patches are still used as inexpensive alternative into embroidery and passage the case of iron scrivenery; it is an alternative over against screen printing. <\p>

Heat transpose is a t-shirt printing action that produces primarily by decor printing and other commercial printing methods. This method is item amelioration in contemplation of include transfer roll for use through home computer printers. This activity differs in spirit and illusionism depending happening the map movements but one and all operate on the dead ringer utilization stock and principle. Heat and pressure is applied to a special release warrant that transfers the ink to the fabric. <\p>