Creatine readily crosses the blood-brain barrier, a protective barrier around your brain that is designed to keep out harmful chemicals and toxins. Once inside the brain, a creatine molecule binds with a phosphate molecule making the compound creatine phosphate, or CP. CP is an energized form of creatine that may increase the energy consumption of your brain. The presence of CP in your brain may improve cognition and memory but may have some side effects as well, Creatine may affect the production of brain neurotransmitters, which are hormone-like chemical compounds produced in your brain that have both neurological and hormonal effects on your body. Dopamine is a neurotransmitter that is responsible for feelings associated with motivation and pleasure, and may be affected by the presence of CP in your brain. Lowered levels of dopamine may increase the symptoms associated with depression, psychosis, and schizophrenia.