Hope for Thyroid Cancer Patients
The incidence of thyroid cancer has been steadily increasing over the last thirty years. Claiming more lives than all the other types of endocrine malignancies put together, thyroid cancer affects over 60,000 people each year in the US alone.
There are five main types of mutations that are known to be associated with thyroid cancer: BRAF, HRAS, KRAS, NRAS, and RET.
BRAF, one of the more common mutations, has two subtypes: AKAP-BRAF and BRAF V600E. Of these, BRAF V600E is the more prevalent.
Historically, BRAF V600E–mutated anaplastic thyroid cancer has been very difficult to treat.
Happily, there’s a new combination therapy that has been demonstrated to be quite promising for this type of cancer. In a recent study, 69% of patients with BRAF V600E–mutant anaplastic thyroid cancer in the study responded to a combination of the BRAF inhibitor Dabrafenib and the MEK inhibitor Trametinib.
Amazingly, the median durations of progression-free survival (PFS), and overall survival (OS) were not reached during the first 2.5 years of the study.
Furthermore, the estimated progression-free survival (PFS) at 12 months was 79% and the overall survival (OS) was 80%.
This is an extremely significant discovery because it’s first time that a therapy has been shown to have robust clinical activity in BRAF V600E–mutant anaplastic thyroid cancer. Read more about the study here: http://www.ascopost.com/News/58232
For patients with BRAF V600E–mutant anaplastic thyroid cancer, this finding can mean the difference between life and death. If you’d like to know whether this combination therapy is likely to be effective for your unique form of thyroid cancer, contact our precision oncology specialists today! We’ll discuss your case in detail and explain the next steps in identifying the most effective treatment for your unique form of cancer.
Feel free to download our brochures to learn more: https://www.ctoam.com/about/brochures/
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