#odefsey

Publishing their findings in HIV Medicine, researchers conducted a multicenter, prospective and observational study of 1,490 people with HIV who started their first antiretroviral (ARV) treatment with Edurant (786 people) or Sustiva (704 people) and were members of the Italian Cohort Native Antiretrovirals Foundation Study. All participants began the study with a viral load below 100,000.

ODEFSEY EMTRICITABINA / RILPIVIRINA / ALAFENAMIDA DE TENOFOVIR. Combinación farmacéutica #odefsey #rilpivirina #alafenamidadetenofovir #alafenamida #emtricitabina #clorhidrato #fumarato #tenofovir #salud #saludybienestar #arv #medic #medicine #medicinas #medicamento #retrovirrales #antiretrovirrales #concienciasocial #conciencia https://www.instagram.com/p/CAyUusYj63r/?igshid=erp5x8jtukum

Odefsey_Gilead

Your doctor is right that it’s theoretical in that it hasn’t been specifically reported, but it would still make me nervous. I would worry that going 10 consecutive days with subtherapeutic rilpivirine levels could be enough to result in viral rebound and resistance. 

If you don’t miss doses, don’t mind taking your meds with a meal, and have a consistently undetectable viral load, then you shouldn’t worry about the resistance barrier of either Eviplera (Complera in the U.S.) or Odefsey. The resistance barrier is more of a concern when we start people on treatment for the first time and we don’t know whether they’ll be good at taking medications.

I try to  avoid giving direct advice on this forum, but in this case it’s hard to avoid it. At the age of 70, you have impaired kidney function and decreased bone density based on your age. The tenofovir DF in Complera will only make that worse. Switching to Odefsey will make it better, so this is an easy decision.

Since Genvoya has no known drug-specific toxicities, there’s nothing special you can do other than to keep yourself generally healthy  and well hydrated and to make sure you’re getting your labs monitored regularly. Since it contains cobicistat, make sure you’re avoiding drugs that interact, including over-the-counter fluticasone (Flonase) nasal spray. 

As for medications to avoid with Genvoya, the list is essentially the same as the list for ritonavir (Norvir). The only over-the-counter medication to avoid is fluticasone (Flonase), a nasal steroid spray used to treat allergy symptoms. There is a long list of prescribed medications that interact. The drugs may not necessarily be contraindicated, but some drugs, such as statins and drugs for erectile dysfunction, should be used at low doses. The list is too long to go into here, but your doctors and pharmacists should always be aware that you’re taking either cobicistat (in Genvoya, Precobix, and Evotaz) or ritonavir (including Norvir and Kaletra) so they can take these interactions into consideration.