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Tosylhydrazine (CAS 1576-35-8) is a high-purity reagent manufactured for pharmaceutical, fine chemical, and research synthesis.

Chemical Overview

Tosylhydrazine, also known as p-toluenesulfonyl hydrazide, is an important sulfonyl hydrazine derivative. It is commonly utilized in organic transformations, particularly in reactions involving carbonyl compounds and nitrogen-based intermediates.

Molecular Formula: C₇H₁₀N₂O₂S

Molecular Weight: 186.23 g/mol

CAS Number: 1576-35-8

Appearance: White to off-white crystalline powder

Melting Point: ~114–118°C

Solubility: Soluble in organic solvents, slightly soluble in water

Key Properties

Tosylhydrazine is valued for its stability and reactivity, making it suitable for a wide range of chemical processes:

High purity and consistent quality

Excellent reactivity with aldehydes and ketones

Stable under standard storage conditions

Versatile intermediate for nitrogen-containing compounds

Applications in Pharmaceutical Industry

In the pharmaceutical sector, Tosylhydrazine is used as an important intermediate for synthesizing active pharmaceutical ingredients (APIs) and drug intermediates.

API synthesis and modification

Formation of hydrazone derivatives

Intermediate in heterocyclic compound synthesis

Used in research for drug discovery and development

Role in Organic and Fine Chemical Synthesis

Tosylhydrazine is widely applied in organic chemistry due to its ability to participate in various important reactions:

Wolff–Kishner reduction (via hydrazone formation)

Preparation of diazo compounds

Synthesis of nitrogen-containing organic molecules

Intermediate in specialty and fine chemicals

Industrial Applications

Its versatility makes Tosylhydrazine valuable across multiple industries:

Agrochemical intermediates

Dye and pigment manufacturing

Specialty chemical production

Polymer and material science research

Specifications

Typical quality specifications for Tosylhydrazine include:

Purity: ≥ 98%

Moisture Content: ≤ 0.5%

Melting Range: 114–118°C

Residue on Ignition: ≤ 0.1%

Storage and Handling

To maintain stability and quality:

Store in a cool, dry, and well-ventilated area

Keep container tightly closed

Protect from moisture and direct sunlight

Avoid exposure to strong oxidizing agents

Safety Information

While Tosylhydrazine is widely used in laboratories and industry, proper safety precautions are essential:

Use appropriate personal protective equipment (PPE)

Avoid inhalation and skin contact

Handle in a well-ventilated environment

Refer to the MSDS for detailed safety and hazard information

Conclusion

Methanesulfonamide (CAS 3144-09-0) is a high-purity chemical used in pharmaceuticals and organic synthesis. Explore its properties, applications, and safety data.

Introduction

Methanesulfonamide (CAS No: 3144-09-0) is an important organic compound belonging to the sulfonamide family. It is widely used in chemical synthesis, pharmaceutical research, and industrial applications. Due to its unique structure and reactivity, Methanesulfonamide serves as a key intermediate in the development of various high-value chemical products.

Chemical Identification

Chemical Name: Methanesulfonamide

CAS Number: 3144-09-0

Molecular Formula: CH₅NO₂S

Molecular Weight: 95.12 g/mol

Synonyms:

Methanesulfonic amide

Methyl sulfonamide

Mesyl amide

Methanesulfonamide is considered the simplest member of sulfonic acid amides, making it highly valuable in organic chemistry research.

Physical and Chemical Properties

Methanesulfonamide exhibits stable physical and chemical characteristics:

Appearance: White to yellow crystalline solid

Melting Point: 85–89°C

Boiling Point: ~208°C (predicted)

Density: ~1.229 g/cm³

Solubility: Slightly soluble in methanol and DMSO

pKa: ~10.87

These properties make it suitable for controlled reactions in laboratory and industrial environments.

Synthesis of Methanesulfonamide

Methanesulfonamide is typically synthesized by:

Reaction of methanesulfonyl chloride with ammonia

Alternative methods include reduction or reactions involving sulfonyl azides

These synthesis routes are widely adopted in chemical manufacturing industries.

Applications and Uses

1. Pharmaceutical Industry

Methanesulfonamide plays a crucial role in drug development:

Used as a reagent in synthesizing medicinal compounds

Helps in producing derivatives like indole-based and pyrimidine-based molecules

2. Organic Synthesis

Acts as a nitrogen source in converting carboxylic acids into nitriles

Used in the preparation of advanced organic intermediates

3. Chemical Research

Widely used in reaction studies and ligand binding analysis

Important in designing biologically active molecules

4. Industrial Applications

Used in the production of specialty chemicals

Involved in the synthesis of brightening agents and other functional compounds

Safety and Handling

Methanesulfonamide should be handled with care:

Classified as an irritant

May cause irritation to eyes, skin, and respiratory system

Recommended precautions:

Wear protective gloves and clothing

Avoid inhalation and direct contact

Store in a dry, sealed container away from light

Storage Guidelines

Store at room temperature

Keep in a cool, dry, and well-ventilated area

Protect from moisture and direct sunlight

Conclusion