#ncats

Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin buildup in the inner ear. They also found a region in the inner ear that could be targeted for efforts to prevent hearing…

Tissue Chips Take Aim at Atherosclerosis and Rheumatoid Arthritis

Biomedical engineers at Duke University have received more than $2 million to develop “tissue chips” that model atherosclerosis and muscle dysfunction in rheumatoid arthritis.  They then plan to link the various models together and examine how simulated exercise can reduce the impact of inflammation.

“People with rheumatoid arthritis and other autoimmune diseases are at higher risk of cardiovascu…

$46 Million Supports Research Likely to Result in New Therapies, Improve Health Care

Washington University School of Medicine in St. Louis has received a $46 million grant from the National Institutes of Health (NIH) to support research aimed at translating scientific and clinical discoveries into new diagnostics and therapeutics, and to more rapidly apply research findings to improve health.

The grant, from the National Center for Advancing Translational Sciences (NCATS),…

Research on New, Rapid Screening Test Identifies Potential Therapies Against Drug-resistant Bacteria

Researchers at the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS), Clinical Center and National Institute of Allergy and Infectious Diseases (NIAID) have created a new way to identify drugsand drug combinations that may potentially be useful in combating infections that are resistant to many different antibiotics. They developed an assay (test) to…

Manufactured Stem Cells to Advance Clinical Research

Researchers supported by the National Institutes of Health developed a clinical-grade stem cell line, which has the potential to accelerate the advance of new medical applications and cell-based therapies for millions of people suffering from such ailments as Alzheimer’s disease, Parkinson’s disease, spinal cord injury, diabetes, and muscular dystrophy. The stem cellswere developed by isolating…