Octocorallian soft corals are known for their ecological and pharmacological importance, but the bioactivity of crude extracts from Philippine species is less studied. This study determined the toxicity of crude extracts from species collected at wave-exposed and less wave-exposed nearshore sites at Talisayan, Southern Philippines. SCUBA diving was used to collect soft coral specimens at 3-5 m depth. In situ colony image and sclerites from each specimen were used to identify soft corals to the species level. The brine shrimp lethality assay was carried out to determine the toxicity of methanol extracts at 10, 100 and 1000 ppm concentrations. This study recorded three species (Sarcophyton crassocaule, Isis hippuris, Cespitularia stolonifera) from the less wave-exposed site, and eight from the wave-exposed area (Sinularia sp., Si. flexibilis, Lobophytum crassum, and L. durum, Si. polydactyla, S. ehrenbergi, S. glaucum, and Dendronephthya hemprichii). Toxicity of extracts against brine shrimps appears not to be due to the wave exposure of site, but more associated with the species and perhaps intensity of fish predation on soft corals. Extracts from S. crassocaule, L. durum, Isis hippuris, L. crassum, S. ehrenbergi, C. stolonifera, and D. hemprichii were highly toxic with LC50 values (in ppm) of 0.40, 3.45, 3.67, 4.25, 4.25, 26.92, and 28.18, respectively. Si. flexibilis was considered toxic with an LC50 value of 144.54 ppm. The unidentified species Sinularia sp. was found to be non-toxic. This study reveals that some soft coral taxa from Talisayan neritic waters are potentially good sources of bioactive compounds for drug discovery.