Targeted elimination of leukemic stem cells

Activated LIGHT/LTbR signaling pathway (left) leads to symmetric cleavage and a propatation of leukemic stem cells. Credit: A. Ochsenbein, University Hospital Bern Leukemia is caused by leukemic stem cells which are resistant to most known therapies. Relapses are also due to this resistance. Leukemic stem cells arise from normal blood-forming (hematopoietic) stem cells. Because they are closely…